Journal article
Local and Intra-articular Administration of Nonsteroidal Anti-inflammatory Drugs for Pain Management in Orthopedic Surgery
American journal of therapeutics, Vol.29(2), pp.E219-E228
10 Dec 2020
PMID: 33315593
Abstract
Background: Although growing evidence demonstrates the benefits of locally administered nonsteroidal anti-inflammatory drugs (NSAIDs) for postoperative pain management, there is ongoing debate regarding NSAID use in orthopedic surgery.
Areas of Uncertainty: Current data largely support a local site of NSAID action and suggest that effective pain control can be achieved with delivery of NSAIDs intra-articularly (IA) and/or locally at the site of injury, where they can block peripheral production of inflammatory mediators and may desensitize nociceptors. Improvements in postoperative pain control with locally administered NSAIDs have been widely reported in the total joint arthroplasty literature and may offer benefits in patient's undergoing arthroscopic procedures and those with osteoarthritis as well. The purpose of this review is to examine the available evidence in the literature regarding the efficacy and safety profile of the use of local and IA NSAIDs in orthopedic surgery. Data Sources: Narrative literature review using keywords, expert opinion, either during or from live conference.
Therapeutic Advances: Local and IA administration of NSAIDs for pain management in orthopedic surgery.
Conclusion: There is convincing evidence that NSAIDs administered locally in and around the joint reduce postoperative pain scores and opioid consumption in patients undergoing total joint arthroplasty, yet further research is required regarding the risks of potential chondrotoxicity and the inhibition of bone and soft-tissue healing with locally administered NSAIDs.
Metrics
1 Record Views
Details
- Title
- Local and Intra-articular Administration of Nonsteroidal Anti-inflammatory Drugs for Pain Management in Orthopedic Surgery
- Creators
- Nicholas M. Bernthal - Ronald Reagan UCLA Medical CenterChristopher M. Hart - University of California, Los AngelesKetan R. Sheth - Harvard UniversitySergio D. Bergese - SUNY Stony Brook, Sch Med, Dept Anesthesiol, Hlth Sci Ctr, Stony Brook, NY 11794 USAHung S. Ho - University of California, DavisChristian C. Apfel - University of California, San FranciscoNicoleta Stoicea - Ohio State Univ, Dept Biol Chem & Pharmacol, Columbus, OH 43210 USAAllen Rojhani - Drexel UniversityJonathan S. Jahr - Univ Calif Los Angeles, Dept Anesthesiol & Perioperat Med, Ronald Reagan UCLA Med Ctr, David Geffen Sch Med, 757 Westwood Plaza,Suite 3325, Los Angeles, CA 90095 USA
- Publication Details
- American journal of therapeutics, Vol.29(2), pp.E219-E228
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 10
- Grant note
- Hospira Pfizer company
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000765922100008
- Scopus ID
- 2-s2.0-85124506293
- Other Identifier
- 991021860718804721
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy