Journal article
Local and global functions of Timeless and Tipin in replication fork protection
Cell cycle (Georgetown, Tex.), v 11(21), pp 3945-3955
01 Nov 2012
PMID: 22987152
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The eukaryotic cell replicates its chromosomal DNA with almost absolute fidelity in the course of every cell cycle. This accomplishment is remarkable considering that the conditions for DNA replication are rarely ideal. The replication machinery encounters a variety of obstacles on the chromosome, including damaged template DNA. In addition, a number of chromosome regions are considered to be difficult to replicate owing to DNA secondary structures and DNA binding proteins required for various transactions on the chromosome. Under these conditions, replication forks stall or break, posing grave threats to genomic integrity. How does the cell combat such stressful conditions during DNA replication? The replication fork protection complex (FPC) may help answer this question. Recent studies have demonstrated that the FPC is required for the smooth passage of replication forks at difficult-to-replicate genomic regions and plays a critical role in coordinating multiple genome maintenance processes at the replication fork.
Metrics
Details
- Title
- Local and global functions of Timeless and Tipin in replication fork protection
- Creators
- Adam R Leman - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USAEishi Noguchi
- Publication Details
- Cell cycle (Georgetown, Tex.), v 11(21), pp 3945-3955
- Publisher
- United States
- Grant note
- F31 AG035480 / NIA NIH HHS R01GM077604 / NIGMS NIH HHS F31AG035480 / NIA NIH HHS R01 GM077604 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000310583500015
- Scopus ID
- 2-s2.0-84869392858
- Other Identifier
- 991014878338204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology