Journal article
Local control and patient survival after stereotactic radiosurgery for esophageal cancer brain metastases: an international multicenter analysis
Journal of neurosurgery, v 142(5), pp 1357-1365
01 May 2025
PMID: 39642356
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study aimed to evaluate local control (LC) of tumors, patient overall survival (OS), and the safety of stereotactic radiosurgery (SRS) for esophageal cancer brain metastases (EBMs).
This retrospective cohort study used data from 15 International Radiosurgery Research Foundation facilities encompassing 67 patients with 185 EBMs managed using SRS between January 2000 and May 2022. The median patient age was 63 years, with a male predominance (92.5%). Most patients (64.2%) had a single brain metastasis, while 7.5% had more than 5 metastases. The median tumor volume was 0.9 cm3, and the median margin dose delivered to the tumor was 20 Gy.
The median OS post-SRS was 15.2 months, with 1- and 2-year OS rates of 65.7% and 32.3%, respectively. A significant inverse correlation was found between the number of EBMs and OS in the univariable analysis. LC rates at 1 and 2 years were 89% and 76%, respectively. Adverse radiation effects (AREs) were observed in 17.9% of patients, with 13.4% being mild and transient and 4.5% severely symptomatic (Common Terminology Criteria for Adverse Events grade 3). New intracranial disease developed in 58.2% of patients, with 1- and 2-year rates of 58% and 73%, respectively.
SRS for EBMs demonstrated high survival rates and effective tumor control, with a low incidence of severe AREs. These findings highlight the potential role of SRS in the multidisciplinary multimodality management paradigm of EBM.
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Details
- Title
- Local control and patient survival after stereotactic radiosurgery for esophageal cancer brain metastases: an international multicenter analysis
- Creators
- Othman Bin-Alamer - University of Pittsburgh Medical CenterHussam Abou-Al-Shaar - University of Pittsburgh Medical CenterRaj Singh - University Health SystemGreg Bowden - University of AlbertaDavid Mathieu - Université de SherbrookeHaley K Perlow - Departments of5Radiation Oncology andJoshua D Palmer - The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteShahed Elhamdani - Departments of7Neurosurgery andMatthew Shepard - Departments of7Neurosurgery andYun Liang - Allegheny Health NetworkAhmed M Nabeel - Nasser Institute hospitalWael A Reda - Nasser Institute hospitalSameh R Tawadros - Nasser Institute hospitalKhaled Abdel Karim - Ain Shams UniversityAmr M N El-Shehaby - Nasser Institute hospitalReem Emad Eldin - Cairo UniversityAhmed Hesham Elazzazi - Ain Shams UniversityRonald E Warnick - Jewish HospitalYair M Gozal - Jewish HospitalMegan Daly - University of PennsylvaniaBrendan McShane - University of PennsylvaniaMarcel Addis-Jackson - University of PennsylvaniaGokul Karthikeyan - University of PennsylvaniaSian Smith - University of PennsylvaniaPiero Picozzi - IRCCS Humanitas Research HospitalAndrea Franzini - IRCCS Humanitas Research HospitalTehila Kaisman-Elbaz - The Neurological InstituteHuai-Che Yang - 20National Yang Ming Chiao Tung University School of Medicine, Hsinchu, TaiwanJudith Hess - Yale UniversityKelsey Templeton - Yale UniversityZhishuo Wei - Neurological SurgeryStylianos Pikis - University of VirginiaGeorgios Mantziaris - Neurological SurgeryGabriela Simonova - Na Homolce HospitalRoman Liscak - Na Homolce HospitalSelcuk Peker - Koç UniversityYavuz SamanciVeronica Chiang - Yale UniversityCheng-Chia Lee - National Yang Ming Chiao Tung UniversityDaniel M Trifiletti - Jacksonville CollegeAjay Niranjan - University of Pittsburgh Medical CenterL Dade Lunsford - University of Pittsburgh Medical CenterJason P Sheehan - Neurological Surgery
- Publication Details
- Journal of neurosurgery, v 142(5), pp 1357-1365
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:001488885700003
- Scopus ID
- 2-s2.0-105004288442
- Other Identifier
- 991022154806404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Surgery