Journal article
Local control and survival after stereotactic radiosurgery for colorectal cancer brain metastases: an international multicenter analysis
Journal of neurosurgery, v 140(5), pp 1233-1242
01 May 2024
PMID: 37948682
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The goal of this study was to characterize local tumor control (LC), overall survival (OS), and safety of stereotactic radiosurgery for colorectal brain metastasis (CRBM).
Ten international institutions participating in the International Radiosurgery Research Foundation provided data for this retrospective case series. This study included 187 patients with CRBM (281 tumors), with a median age of 62 years and 56.7% being male. Most patients (53.5%) had solitary tumors, although 10.7% had > 5 tumors. The median tumor volume was 2.7 cm3 (IQR 0.22-8.1 cm3), and the median margin dose was 20 Gy (IQR 18-22 Gy).
The 3-year LC and OS rates were 72% and 20%, respectively. Symptomatic adverse radiation effects occurred in 1.6% of patients. In the multivariate analysis, age > 65 years and tumor volume > 4.0 cm3 were significant predictors of tumor progression (hazard ratio [HR] 2.6, 95% CI 1.4-4.9; p = 0.003 and HR 3.4, 95% CI 1.7-6.9; p < 0.001, respectively). Better performance status (Karnofsky Performance Scale score > 80) was associated with a reduced risk of tumor progression (HR 0.38, 95% CI 0.19-0.73; p = 0.004). Patient age > 62 years (HR 1.6, 95% CI 1.1-2.3; p = 0.03) and the presence of active extracranial disease (HR 1.7, 95% CI 1.1-2.4; p = 0.009) were significantly associated with worse OS.
Stereotactic radiosurgery offers a high LC rate and a low rate of symptomatic adverse radiation effects for the majority of CRBMs. The OS and LC favored younger patients with high functional performance scores and inactive extracranial disease.
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Details
- Title
- Local control and survival after stereotactic radiosurgery for colorectal cancer brain metastases: an international multicenter analysis
- Creators
- Othman Bin-Alamer - University of Pittsburgh Medical CenterHussam Abou-Al-Shaar - University of Pittsburgh Medical CenterRaj Singh - University Health SystemArka N Mallela - University of Pittsburgh Medical CenterAndrew Legarreta - University of Pittsburgh Medical CenterGreg Bowden - University of AlbertaDavid Mathieu - Université de SherbrookeHaley K Perlow - Departments of5Radiation Oncology andJoshua D Palmer - The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteShahed Elhamdani - Departments of7Neurosurgery andMatthew Shepard - Departments of7Neurosurgery andYun Liang - Allegheny Health NetworkAhmed M Nabeel - Nasser Institute hospitalWael A Reda - Nasser Institute hospitalSameh R Tawadros - Nasser Institute hospitalKhaled Abdelkarim - Ain Shams UniversityAmr M N El-Shehaby - Nasser Institute hospitalReem Emad Eldin - Cairo UniversityAhmed Hesham Elazzazi - Ain Shams UniversityRonald E Warnick - Jewish HospitalYair M Gozal - Jewish HospitalMegan Daly - University of PennsylvaniaBrendan McShane - University of PennsylvaniaMarcel Addis-Jackson - University of PennsylvaniaGokul Karthikeyan - University of PennsylvaniaSian Smith - University of PennsylvaniaPiero Picozzi - IRCCS Humanitas Research HospitalAndrea Franzini - IRCCS Humanitas Research HospitalTehila Kaisman-Elbaz - The Neurological InstituteHuai-Che Yang - 20National Yang Ming Chiao Tung University School of Medicine, Hsinchu, TaiwanJudith Hess - Yale UniversityKelsey Templeton - Yale UniversityXiaoran Zhang - University of Pittsburgh Medical CenterZhishuo Wei - Neurological SurgeryStylianos Pikis - Departments of22Neurological Surgery andGeorgios Mantziaris - Departments of22Neurological Surgery andGabriela Simonova - Na Homolce HospitalRoman Liscak - Na Homolce HospitalSelcuk Peker - Koç UniversityYavuz SamanciVeronica Chiang - Yale UniversityCharles R Kersh - University of VirginiaCheng-Chia Lee - Taipei Veterans General HospitalDaniel M Trifiletti - Jacksonville CollegeAjay Niranjan - University of Pittsburgh Medical CenterConstantinos G Hadjipanayis - University of Pittsburgh Medical CenterL Dade Lunsford - University of Pittsburgh Medical CenterJason P Sheehan - Yale University
- Publication Details
- Journal of neurosurgery, v 140(5), pp 1233-1242
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:001241850800004
- Scopus ID
- 2-s2.0-85192112804
- Other Identifier
- 991022154806204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Surgery