Journal article
Local delivery of thyroid hormone enhances oligodendrogenesis and myelination after spinal cord injury
Journal of neural engineering, v 14(3), pp 036014/1-036014/13
30 Mar 2017
PMID: 28358726
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective. Traumatic spinal cord injury (SCI) causes apoptosis of myelin-forming oligodendrocytes (OLs) and demyelination of surviving axons, resulting in conduction failure. Remyelination of surviving denuded axons provides a promising therapeutic target for spinal cord repair. While cell transplantation has demonstrated efficacy in promoting remyelination and functional recovery, the lack of ideal cell sources presents a major obstacle to clinical application. The adult spinal cord contains oligodendrocyte precursor cells and multipotent neural stem/progenitor cells that have the capacity to differentiate into mature, myelinating OLs. However, endogenous oligodendrogenesis and remyelination processes are limited by the upregulation of remyelination-inhibitory molecules in the post-injury microenvironment. Multiple growth factors/molecules have been shown to promote OL differentiation and myelination. Approach. In this study we screened these therapeutics and found that 3, 3′, 5-triiodothyronine (T3) is the most effective in promoting oligodendrogenesis and OL maturation in vitro. However, systemic administration of T3 to achieve therapeutic doses in the injured spinal cord is likely to induce hyperthyroidism, resulting in serious side effects. Main results. In this study we developed a novel hydrogel-based drug delivery system for local delivery of T3 to the injury site without eliciting systemic toxicity. Significance. Using a clinically relevant cervical contusion injury model, we demonstrate that local delivery of T3 at doses comparable to safe human doses promoted new mature OL formation and myelination after SCI.
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Details
- Title
- Local delivery of thyroid hormone enhances oligodendrogenesis and myelination after spinal cord injury
- Creators
- Robert B Shultz - Drexel UniversityZhicheng Wang - Drexel University School of Biomedical Engineering, Science and Health Systems, 3141 Chestnut Street, Philadelphia, PA 19104, United States of AmericaJia Nong - Drexel University School of Biomedical Engineering, Science and Health Systems, 3141 Chestnut Street, Philadelphia, PA 19104, United States of AmericaZhiling Zhang - Drexel University School of Biomedical Engineering, Science and Health Systems, 3141 Chestnut Street, Philadelphia, PA 19104, United States of AmericaYinghui Zhong - Drexel University
- Publication Details
- Journal of neural engineering, v 14(3), pp 036014/1-036014/13
- Publisher
- IOP Publishing
- Number of pages
- 13
- Grant note
- Start-up Fund / Drexel University (https://doi.org/10.13039/100008211)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000398266300004
- Scopus ID
- 2-s2.0-85020486317
- Other Identifier
- 991019167341504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Engineering, Biomedical
- Neurosciences