Journal article
Localized Delivery of Dexamethasone from Electrospun Fibers Reduces the Foreign Body Response
Biomacromolecules, v 13(10), pp 3031-3038
08 Oct 2012
PMID: 22920794
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Synthetic scaffolds are crucial to applications in regenerative medicine; however, the foreign body response can impede regeneration and may lead to failure of the implant. Herein we report the development of a tissue engineering scaffold that allows attachment and proliferation of regenerating cells while reducing the foreign body response by localized delivery of an anti-inflammatory agent. Electrospun fibers composed of poly(L-lactic) acid (PLLA) and poly(epsilon-caprolactone) (PCL) were prepared with and without the steroid anti-inflammatory drug, dexamethasone. Analysis of subcutaneous implants demonstrated that the PLLA fibers encapsulating dexamethasone evoked a less severe inflammatory response than the other fibers examined. They also displayed a controlled release of dexamethasone over a period of time conducive to tissue regeneration and allowed human mesenchymal stem cells to adhere to and proliferate on them in vitro. These observations demonstrate their potential as a building block for tissue engineering scaffolds.
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Details
- Title
- Localized Delivery of Dexamethasone from Electrospun Fibers Reduces the Foreign Body Response
- Creators
- Nathaniel M. Vacanti - MIT, Dept Chem Engn, Cambridge, MA 02139 USAHao Cheng - MIT, Dept Chem Engn, Cambridge, MA 02139 USAPaulina S. Hill - MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USAJoao D. T. Guerreiro - Institute for Biotechnology and BioengineeringTram T. Dang - Boston Children's HospitalMinglin Ma - MIT, Dept Chem Engn, Cambridge, MA 02139 USAShanee Watson - MIT, Dept Chem Engn, Cambridge, MA 02139 USANathaniel S. Hwang - MIT, Dept Chem Engn, Cambridge, MA 02139 USARobert Langer - Boston Children's HospitalDaniel G. Anderson - Boston Children's Hospital
- Publication Details
- Biomacromolecules, v 13(10), pp 3031-3038
- Publisher
- Amer Chemical Soc
- Number of pages
- 8
- Grant note
- SFRH/BD/35686/2007 / Fundao para a Cincia e a Tecnologia 17-2007-1063 / Juvenile Diabetes Research Foundation W81XWH-08-2-0034 / Armed Forces Institute of Regenerative Medicine DE016516; DE01323 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA MIT-Portugal Program SFRH/BD/35686/2007 / Fundacao para a Ciencia e Tecnologia; Fundacao para a Ciencia e a Tecnologia (FCT)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000309488600003
- Scopus ID
- 2-s2.0-84867439224
- Other Identifier
- 991021886374204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Organic
- Polymer Science