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Journal article
Localized Intra-Cavitary Therapy to Drive Systemic Anti-Tumor Immunity
Frontiers in immunology, v 13, pp 846235-846235
2022
PMID: 35222439
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Metastasis to the pleural and peritoneal cavities is a common terminal pathway for a wide variety of cancers. This article explores how these unique environments both promote aggressive tumor behavior and suppresses anti-tumor immunity, and ways in which local delivery of protein therapeutics can leverage the contained nature of these spaces to a therapeutic advantage, achieving high intra-cavital concentrations while minimizing systemic toxicity.
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Details
- Title
- Localized Intra-Cavitary Therapy to Drive Systemic Anti-Tumor Immunity
- Creators
- Vera S Donnenberg - University of PittsburghPatrick L Wagner - Drexel UniversityJames D Luketich - University of PittsburghDavid L Bartlett - Drexel UniversityAlbert D Donnenberg - University of Pittsburgh
- Publication Details
- Frontiers in immunology, v 13, pp 846235-846235
- Publisher
- Frontiers
- Grant note
- P30 CA047904 / NCI NIH HHS R21 CA191647 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery; General Internal Medicine
- Web of Science ID
- WOS:000761419700001
- Scopus ID
- 2-s2.0-85125323309
- Other Identifier
- 991019167981804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology