Journal article
Localized surface functionalization of polycaprolactone with atmospheric-pressure microplasma jet
Biomedical physics & engineering express, v 1(2), p25002
01 Aug 2015
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Surface properties of biopolymers are crucial for providing topographical and chemical cues to affect cellular behaviors, such as attachment, spreading, viability, proliferation, and differentiation. As an effective surface modification technique, plasma treatment is often applied to enhance surface wettability, adhesion, and biocompatibility of polymers. In this study, an atmospheric-pressure microplasma jet based on dielectric barrier discharge was installed on an automated arm which allows movement in the x-y-z directions at various trajectory presets. Polycaprolactone (PCL) samples were functionalized with helium-oxygen plasma generated by this system and characterized via water contact angle, x-ray photoelectron spectroscopy, and scanning electron microscopy. Mouse osteoblast cells (7F2) were cultured on both treated and native PCL samples and examined by MarkerGene (TM) Live: Dead/Cytotoxicity and alamarBlue (R) assaying techniques. The surface and biological characterization results indicate that microplasma treatment improved surface hydrophilicity, as well as cell viability and proliferation. The localized microplasma treatment can lead to the application of bioactive scaffolds with selective surface functionalization.
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Details
- Title
- Localized surface functionalization of polycaprolactone with atmospheric-pressure microplasma jet
- Creators
- Chengyang Wang - Drexel UniversityQudus Hamid - Drexel UniversityJessica Snyder - Drexel UniversityHalim Ayan - University of ToledoWei Sun - Drexel University
- Publication Details
- Biomedical physics & engineering express, v 1(2), p25002
- Publisher
- Iop Publishing Ltd
- Number of pages
- 11
- Grant note
- 1030520 / National Science Foundation; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000422559400002
- Other Identifier
- 991019167331304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging