Journal article
Locomotor Rhythm Generation Linked to the Output of Spinal Shox2 Excitatory Interneurons
Neuron (Cambridge, Mass.), v 80(4), pp 920-933
20 Nov 2013
PMID: 24267650
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilaterally projecting excitatory interneuron population, marked by the expression of Shox2 that overlaps partially with V2a interneurons. Optogenetic silencing or blocking synaptic output of Shox2 interneurons (INs) in transgenic mice perturbed rhythm without an effect on pattern generation, whereas ablation of the Shox2 IN subset coinciding with the V2a population was without effect. Most Shox2 INs are rhythmically active during locomotion and analysis of synaptic connectivity showed that Shox2 INs contact other Shox2 INs, commissural neurons, and motor neurons, with preference for flexor motor neurons. Our findings focus attention on a subset of Shox2 INs that appear to participate in the rhythm-generating kernel for spinal locomotion.
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Details
- Title
- Locomotor Rhythm Generation Linked to the Output of Spinal Shox2 Excitatory Interneurons
- Creators
- Kimberly J. Dougherty - Karolinska InstitutetLaskaro Zagoraiou - Biomedical Research Foundation of the Academy of AthensDaisuke Satoh - University of BaselIsmini Rozani - Biomedical Research Foundation of the Academy of AthensStaceyann Doobar - Howard Hughes Medical InstituteSilvia Arber - University of BaselThomas M. Jessell - Howard Hughes Medical InstituteOle Kiehn - Karolinska Institutet
- Publication Details
- Neuron (Cambridge, Mass.), v 80(4), pp 920-933
- Publisher
- Elsevier
- Number of pages
- 14
- Grant note
- HHMI; Howard Hughes Medical Institute Swedish Research Council; European Commission National Science Foundation IRFP NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Helen Hay Whitney Foundation Novartis Research Foundation Marie Curie Reintegration Grant; European Commission Swiss National Science Foundation; Swiss National Science Foundation (SNSF); European Commission Torsten and Ragnar Soderberg Foundations ProjectALS StratNeuro BRFAA ERC; European Research Council (ERC); European Commission Kanton Basel-Stadt
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine; Drexel University
- Web of Science ID
- WOS:000327281200010
- Scopus ID
- 2-s2.0-84888042461
- Other Identifier
- 991020100201104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences