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Journal article
Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6
Proceedings of the National Academy of Sciences - PNAS, v 90(8), pp 3700-3704
15 Apr 1993
PMID: 8475118
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Abstract
Pertussis toxin (PTX) is the primary component responsible for eliciting the majority of biological activities associated with Bordetella pertussis, including the induction of several tissue-adjuvant models of organ-specific autoimmune disease. PTX, when administered in vivo, enhances vascular permeability, which is made manifest by a concomitant increase in sensitivity to a variety of agents and treatments affecting the vascular bed. One such agent is histamine, and the response to PTX, as measured by hypersensitivity following vasoactive amine challenge, is genetically controlled by the Bphs locus. Susceptibility to the induction of both experimental allergic encephalomyelitis (EAE) and experimental allergic orchitis (EAO) in mice is associated with, and in the latter case linked to, a susceptible allele at this locus. We report here the mapping of the Bphs locus to mouse chromosome 6, telomeric of Tcrb and centromeric of Prp (D6Nds8). This region also contains a number of loci of immunologic relevance including Igk, Ly-2, Ly-3, Il-5r, Ly-35, Ly-4, and Tnfr-2.
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Details
- Title
- Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6
- Creators
- J D Sudweeks - Brigham Young UniversityJ A Todd - Brigham Young UniversityE P Blankenhorn - Brigham Young UniversityB B Wardell - Brigham Young UniversityS R Woodward - Brigham Young UniversityN D Meeker - Brigham Young UniversityS S Estes - Brigham Young UniversityC Teuscher - Brigham Young University
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 90(8), pp 3700-3704
- Publisher
- PNAS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1993KX81600121
- Scopus ID
- 2-s2.0-0027516843
- Other Identifier
- 991019183988904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology