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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Loneliness, Depression, and Inflammation: Evidence from the Multi-Ethnic Study of Atherosclerosis
PloS one, v 11(7), pp e0158056-e0158056
01 Jul 2016
PMID: 27367428
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective
Both objective and subjective aspects of social isolation have been associated with alterations in immune markers relevant to multiple chronic diseases among older adults. However, these associations may be confounded by health status, and it is unclear whether these social factors are associated with immune functioning among relatively healthy adults. The goal of this study was to examine the associations between perceived loneliness and circulating levels of inflammatory markers among a diverse sample of adults.
Methods
Data come from a subset of the Multi-Ethnic Study of Atherosclerosis (n = 441). Loneliness was measured by three items derived from the UCLA Loneliness Scale. The association between loneliness and C-reactive protein (CRP) and fibrinogen was assessed using multivariable linear regression analyses. Models were adjusted for demographic and health characteristics.
Results
Approximately 50% of participants reported that they hardly ever felt lonely and 17.2% felt highly lonely. Individuals who were unmarried/unpartnered or with higher depressive symptoms were more likely to report being highly lonely. There was no relationship between perceived loneliness and ln(CRP) (beta = -0.051, p = 0.239) adjusting for demographic and health characteristics. Loneliness was inversely associated with ln(fibrinogen) (beta = -0.091, p = 0.040), although the absolute magnitude of this relationship was small.
Conclusion
These results indicate that loneliness is not positively associated with fibrinogen or CRP among relatively healthy middle-aged adults.
Metrics
Details
- Title
- Loneliness, Depression, and Inflammation: Evidence from the Multi-Ethnic Study of Atherosclerosis
- Creators
- Briana Mezuk - Virginia Commonwealth UniversityMoon Choi - Korea Advanced Institute of Science and TechnologyAmy S. DeSantis - RAND CorporationStephen R. Rapp - Wake Forest UniversityAna V. Diez Roux - Drexel UniversityTeresa Seeman - University of California, Los Angeles
- Publication Details
- PloS one, v 11(7), pp e0158056-e0158056
- Publisher
- Public Library Science
- Number of pages
- 10
- Grant note
- NRF-2015S1A5A8018593 / National Research Foundation of Korea K01-MH093642 / NIH (National Institute of Mental Health); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) N01-HC-95159; N01-HC-95160; N01-HC-95161; N01-HC-95162; N01-HC-95163; N01-HC-95164; N01-HC-95165; N01-HC-95166; N01-HC-95167; N01-HC-95168; N01-HC-95169; R01-HL101161 / NIH (National Heart, Lung, and Blood Institute); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) P60MD002249 / National Institute on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000378914900016
- Scopus ID
- 2-s2.0-85025097975
- Other Identifier
- 991019168829904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Psychiatry