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Journal article
Long-Term Ambient Air Pollution Exposures and Circulating and Stimulated Inflammatory Mediators in a Cohort of Midlife Adults
Environmental health perspectives, v 129(5), pp 57007-57007
01 May 2021
PMID: 34014775
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Chronic exposure to air pollution may prime the immune system to be reactive, increasing inflammatory responses to immune stimulation and providing a pathway to increased risk for inflammatory diseases, including asthma and cardiovascular disease. Although long-term exposure to ambient air pollution has been associated with increased circulating markers of inflammation, it is unknown whether it also relates to the magnitude of inflammatory response.
OBJECTIVES: The aim of this study was to examine associations between chronic ambient pollution exposures and circulating and stimulated levels of inflammatory mediators in a cohort of healthy adults.
METHODS: Circulating interleukin (IL)-6,C-reactive protein (CRP) (n = 392), and lipopolysaccharide stimulated production of IL-beta, IL-6, and tumor necrosis factor (TNF)-alpha (n = 379) were measured in the Adult Health and Behavior II cohort. Fine particulate matter [particulate matter with aerodynamic diameter less than or equal to 2.5 mu m (PM2.5)] and constituents [black carbon (BC), and lead (Pb), manganese (Mn), zinc (Zn), and iron (Fe)] were estimated for each residential address using hybrid dispersion land use regression models. Associations between pollutant exposures and inflammatory measures were examined using linear regression; models were adjusted for age, sex, race, education, smoking, body mass index, and month of blood draw.
RESULTS: There were no significant correlations between circulating and stimulated measures of inflammation. Significant positive associations were found between exposure to PM2.5 and BC with stimulated production of IL-6, IL-beta, and TNF-alpha. Pb, Mn, Fe, and Zn exposures were positively associated with stimulated production of IL-beta and TNF-alpha. No pollutants were associated with circulating IL-6 or CRP levels.
DISCUSSION: Exposure to PM2.5, BC, Pb, Mn, Fe, and Zn was associated with increased production of inflammatory mediators by stimulated immune cells. In contrast, pollutant exposure was not related to circulating markers of inflammation. These results suggest that chronic exposure to some pollutants may prime immune cells to mount larger inflammatory responses, possibly contributing to increased risk for inflammatory disease.
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Details
- Title
- Long-Term Ambient Air Pollution Exposures and Circulating and Stimulated Inflammatory Mediators in a Cohort of Midlife Adults
- Creators
- Sheila Tripathy - Drexel UniversityAnna L. Marsland - University of PittsburghEllen J. Kinnee - University of PittsburghBrett J. Tunno - University of PittsburghStephen B. Manuck - University of PittsburghPeter J. Gianaros - University of PittsburghJane E. Clougherty - University of Pittsburgh
- Publication Details
- Environmental health perspectives, v 129(5), pp 57007-57007
- Publisher
- Us Dept Health Human Sciences Public Health Science
- Number of pages
- 10
- Grant note
- P01-040962 / Biobehavioral Studies of Cardiovascular Disease, National Heart, Lung, and Blood Institute
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000671079000016
- Scopus ID
- 2-s2.0-85106590522
- Other Identifier
- 991019167687004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology