Journal article
Long-Term Recruitment of Endogenous M2 Macrophages by Platelet Lysate-Rich Plasma Macroporous Hydrogel Scaffold for Articular Cartilage Defect Repair
Advanced healthcare materials, v 11(6), 2101661
01 Mar 2022
PMID: 34969180
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
After cartilage damage, a large number of monocytes/macrophages infiltrate into adjacent synovium and the resident macrophages in synovial tissue transform to activated macrophages (M1), which secrete pro-inflammatory cytokines to induce sustained inflammation and chondrocyte apoptotic. However, current clinical therapies for cartilage repair can rarely achieve long-term anti-inflammatory regulation and satisfactory outcomes. Herein, a platelet lysate-rich plasma macroporous hydrogel (PLPMH) scaffold with around 100 mu m pore size and 1.25 MPa Young's modulus is developed to sustainedly recruit and polarize endogenous anti-inflammatory macrophages (M2) for improving cartilage defect repair. PLPMH scaffold can steadily release sphingosine1-phosphate and proteins via gradual degradation, thus inducing M2 macrophages migration or resting (M0) macrophages migration and then polarization to M2 phenotype, and improving the secretion of anti-inflammatory cytokines. Furthermore, PLPMH scaffold exhibits negligible inflammatory responses in vivo and promotes endogenous M2 macrophage infiltration in large numbers and long-time duration to provide a local anti-inflammatory microenvironment, which even lasts for 42 d. In a rabbit model of cartilage defect, PLPMH scaffold increases the ratio of M2 macrophages and improves cartilage tissue regeneration. These studies support that PLPMH scaffold may have a great potential in articular cartilage tissue engineering by providing an anti-inflammatory and pro-regenerative microenvironment.
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Details
- Title
- Long-Term Recruitment of Endogenous M2 Macrophages by Platelet Lysate-Rich Plasma Macroporous Hydrogel Scaffold for Articular Cartilage Defect Repair
- Creators
- Xiaoyun Pan - Wenzhou Medical UniversityShanshan Yuan - University of Chinese Academy of SciencesXiaojie Xun - University of Chinese Academy of SciencesZhiyuan Fan - Drexel Univ, Philadelphia, PA 19104 USAXinghe Xue - Wenzhou Medical UniversityChanghuan Zhang - University of Chinese Academy of SciencesJilong Wang - Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325000, Zhejiang, Peoples R ChinaJunjie Deng - Wenzhou Med Univ, Dept Orthopaed, Affiliated Hosp 2, Wenzhou 325000, Zhejiang, Peoples R China
- Publication Details
- Advanced healthcare materials, v 11(6), 2101661
- Publisher
- Wiley
- Number of pages
- 14
- Grant note
- ZJGK1804Y / Key Laboratory of Orthopaedics of Zhejiang Province LR20C100001 / Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholar WIUCASQD2019004 / Wenzhou Institute, University of Chinese Academy of Sciences 31971260 / National Nature Science Foundation of China; National Natural Science Foundation of China (NSFC) LY19C100002; LY21H060008 / Zhejiang Provincial Natural Science Foundation of China; Natural Science Foundation of Zhejiang Province Y20190136 / Wenzhou Scientific Research Project
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000739897400001
- Scopus ID
- 2-s2.0-85122672005
- Other Identifier
- 991021861298504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials
- Nanoscience & Nanotechnology