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Long-term Exposure to Air Pollution and Markers of Inflammation, Coagulation, and Endothelial Activation A Repeat-measures Analysis in the Multi-Ethnic Study of Atherosclerosis (MESA)
Journal article   Open access   Peer reviewed

Long-term Exposure to Air Pollution and Markers of Inflammation, Coagulation, and Endothelial Activation A Repeat-measures Analysis in the Multi-Ethnic Study of Atherosclerosis (MESA)

Anjum Hajat, Matthew Allison, Ana V. Diez-Roux, Nancy Swords Jenny, Neal W. Jorgensen, Adam A. Szpiro, Sverre Vedal and Joel D. Kaufman
Epidemiology (Cambridge, Mass.), v 26(3), pp 310-320
01 May 2015
DOI: https://doi.org/10.1097/EDE.0000000000000267
PMID: 25710246
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://journals.lww.com/epidem/Fulltext/2015/05000/Long_term_Exposure_to_Air_Pollution_and_Markers_of.4.aspxView
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Life Sciences & Biomedicine Public, Environmental & Occupational Health Science & Technology ESI Highly Cited Paper (Incites)
Background: Air pollution is associated with cardiovascular disease, and systemic inflammation may mediate this effect. We assessed associations between long-and short-term concentrations of air pollution and markers of inflammation, coagulation, and endothelial activation. Methods: We studied participants from the Multi-Ethnic Study of Atherosclerosis from 2000 to 2012 with repeat measures of serum C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen, D-dimer, soluble E-selectin, and soluble Intercellular Adhesion Molecule-1. Annual average concentrations of ambient fine particulate matter (PM2.5), individual-level ambient PM2.5 (integrating indoor concentrations and time-location data), oxides of nitrogen (NOx), nitrogen dioxide (NO2), and black carbon were evaluated. Short-term concentrations of PM2.5 reflected the day of blood draw, day prior, and averages of prior 2-, 3-, 4-, and 5-day periods. Random-effects models were used for long-term exposures and fixed effects for short-term exposures. The sample size was between 9,000 and 10,000 observations for CRP, IL-6, fibrinogen, and D-dimer; approximately 2,100 for E-selectin; and 3,300 for soluble Intercellular Adhesion Molecule-1. Results: After controlling for confounders, 5 mu g/m(3) increase in long-term ambient PM2.5 was associated with 6% higher IL-6 (95% confidence interval = 2%, 9%), and 40 parts per billion increase in long-term NOx was associated with 7% (95% confidence interval = 2%, 13%) higher level of D-dimer. PM2.5 measured at day of blood draw was associated with CRP, fibrinogen, and E-selectin. There were no other positive associations between blood markers and short-or long-term air pollution. Conclusions: These data are consistent with the hypothesis that long-term exposure to air pollution is related to some markers of inflammation and fibrinolysis.

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203 citations in Web of Science
212 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#11 Sustainable Cities and Communities
#3 Good Health and Well-Being

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Highly Cited Paper 
Collaboration types
Domestic collaboration
Web of Science research areas
Public, Environmental & Occupational Health
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