Journal article
Long-term Follow-up After Anti-reflux Surgery in Patients with Barrett's Esophagus
Journal of gastrointestinal surgery, v 14(10), pp 1483-1490
01 Oct 2010
PMID: 20824377
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Factors associated with the risk of progression of Barrett's esophagus remain unclear, and the impact of therapy on this risk remains uncertain. The aim of this study was to assess patients followed long-term after anti-reflux surgery for Barrett's esophagus.
A retrospective review was performed of all patients with Barrett's who underwent anti-reflux surgery from 1989 to 2009 and had a parts per thousand yen5 years of follow-up.
There were 303 patients and 75 had follow-up a parts per thousand yen5 years. Median follow-up time for the 75 patients was 8.9 years (range 5-18). Regression was seen in 31%. Progression occurred in 8%, and these patients were significantly more likely to have a failed fundoplication (67% vs. 16%, p = 0.0129). The rate of progression from non-dysplastic Barrett's to high-grade dysplasia or cancer was 0.8% per patient year, and was seven times higher in patients with a failed fundoplication.
Compared to the accepted rate of progression of non-dysplastic Barrett's to high-grade dysplasia or cancer of 1.0% per patient year, anti-reflux surgery reduces this rate during long-term follow-up. The rate of progression was significantly lower in patients with an intact compared to a disrupted fundoplication, further suggesting that anti-reflux surgery can alter the natural history of Barrett's esophagus.
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Details
- Title
- Long-term Follow-up After Anti-reflux Surgery in Patients with Barrett's Esophagus
- Creators
- Joerg Zehetner - University of Southern CaliforniaSteven R. DeMeester - University of Southern CaliforniaShahin Ayazi - University of Southern CaliforniaJesse L. Costales - University of Southern CaliforniaFlorian Augustin - University of Southern CaliforniaArzu Oezcelik - University of Southern CaliforniaJohn C. Lipham - University of Southern CaliforniaHelen J. Sohn - University of Southern CaliforniaJeffrey A. Hagen - University of Southern CaliforniaTom R. DeMeester - University of Southern California
- Publication Details
- Journal of gastrointestinal surgery, v 14(10), pp 1483-1490
- Publisher
- Springer Nature
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000282101500002
- Scopus ID
- 2-s2.0-77957020874
- Other Identifier
- 991022048377904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Gastroenterology & Hepatology
- Surgery