Journal article
Long-term complete remission inbladder carcinoma in situ with intravesical tice bacillus Calmette guerin
Urology (Ridgewood, N.J.), v 38(6), pp 507-513
1991
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Abstract
Carcinoma in situ is a form of superficial transitional cell carcinoma, which is characterized by a lateral spread along the bladder epithelium, with high-grade malignancy and poor prognosis. Early radical cystectomy is considered the definitive treatment even in the absence of associated invasive cancer. In six prospective phase II studies, 123 carcinoma in situ patients were administered intravesical TICE bacillus Calmette-Guerin (BCG). Treatment consisted of at least six weekly instillations (induction) followed by twelve monthly instillations (maintenance) of BCG (50 mg: 1 to 8 × 10
8 colony-forming units). Of 119 evaluable patients, 90 (76%) achieved complete remission including 45 of 63 (71 %) patients who received prior intravesical chemotherapy. Forty-five responders (50 %) remain in complete remission with negative urine cytology with a median duration of response projected to be ≥ forty-eight months. There is no difference in survival between BCG responders and nonresponders, but there is a significant difference in cystectomy rates: 10 of 90 (11 %) responders vs. 16 of 29 (55 %) nonresponders (
P < 0. 0001, Fisher's exact test) and time to cystectomy (31 vs. 74 mos.) (
P <0.001, log-rank test). Delaying cystectomy does not seem to affect survival and improves quality of life. Treatment was well tolerated with some major adverse effects. Intravesical TICE BCG is an effective treatment for bladder carcinoma in situ patients with or without prior chemotherapy.
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Details
- Title
- Long-term complete remission inbladder carcinoma in situ with intravesical tice bacillus Calmette guerin
- Creators
- R. De Jager - Organon InternationalE. Guinan - Organon InternationalD. Lamm - Organon InternationalO. Khanna - Organon InternationalS. Brosman - Organon InternationalJ. De Kernion - Organon InternationalR. Williams - Organon InternationalC. Richardson - Organon InternationalL. Muenz - Organon InternationalD. Reitsma - Organon InternationalM.G. Hanna - Organon International
- Publication Details
- Urology (Ridgewood, N.J.), v 38(6), pp 507-513
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Management
- Web of Science ID
- WOS:A1991GU28800002
- Scopus ID
- 2-s2.0-0025888356
- Other Identifier
- 991019184102004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Urology & Nephrology