Journal article
Long-term dietary intervention influence on physical activity in the Women’s Health Initiative Dietary Modification randomized trial
Breast cancer research and treatment, v 195(1)
2022
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose
In the Women’s Health Initiative (WHI) Dietary Modification (DM) randomized trial, dietary intervention significantly reduced breast cancer mortality (
P
= 0.02). In observational studies, physical activity is associated with lower breast cancer incidence. Currently, dietary intervention influence on other health-related behaviors is unknown. Therefore, we evaluated whether the WHI dietary intervention influenced self-directed physical activity.
Methods
Of 48,835 postmenopausal women, 19,541 were randomized to dietary intervention (18 nutritionist-led group sessions first year, then quarterly sessions throughout 8.5 years [median] intervention) and 29,294 to a usual diet comparison (written health-related materials only). Neither randomization group received specific or ongoing instructions to increase physical activity. Episodes per week of moderate or vigorous recreational physical activity (MVPA) were serially reported. Marginal longitudinal logistic regression models were used to assess physically inactive (MVPA = 0) or physically active (MVPA > 0) participants by randomization group. Marginal Poisson regression models estimated mean weekly MVPA.
Results
At entry, 45.6% of all participants reported physical inactivity (MVPA = 0). In 43,760 women with MVPA information, throughout 15.9 years (median) cumulative follow-up, dietary intervention group participation was associated with 7% lower physical inactivity rate (odds ratio [OR] 0.93, 95% confidence interval [CI] 0.91, 0.95,
P
< 0.001) and a 4% higher mean MVPA (ratio of means [RM] 1.04 95% CI 1.02, 1.06,
P
< 0.001), relative to the comparison group.
Conclusion
In a randomized trial setting, a low-fat dietary pattern intervention was associated with a long-term, favorable influence on self-directed recreational physical activity.
Trial registration
: NCT00000611.
Metrics
Details
- Title
- Long-term dietary intervention influence on physical activity in the Women’s Health Initiative Dietary Modification randomized trial
- Creators
- Kathy Pan - Kaiser PermanenteAaron K. Aragaki - Fred Hutchinson Cancer Research CenterYvonne Michael - Drexel UniversityCynthia A. Thomson - University of ArizonaLinda G. Snetselaar - University of Iowa Hospitals and ClinicsJean Wactawski-Wende - University at Buffalo, State University of New YorkDavid O. Garcia - Dana-Farber Cancer InstituteChristina M. Dieli-Conwright - Dana-Farber Cancer InstituteAladdin H. Shadyab - Human LongevityNazmus Saquib - Sulaiman Al Rajhi CollegesRowan T. Chlebowski - Los Angeles Biomedical Research Institute
- Publication Details
- Breast cancer research and treatment, v 195(1)
- Publisher
- Springer US
- Grant note
- N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, and 44221. R25CA203650 / Foundation for the National Institutes of Health (http://dx.doi.org/10.13039/100000009)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000823412800001
- Scopus ID
- 2-s2.0-85134076216
- Other Identifier
- 991019167455604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology