Journal article
Long-term exposure to air pollution and type 2 diabetes mellitus in a multiethnic cohort
American journal of epidemiology, v 181(5), pp 327-336
01 Mar 2015
PMID: 25693777
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although air pollution has been suggested as a possible risk factor for type 2 diabetes mellitus (DM), results from existing epidemiologic studies have been inconsistent. We investigated the associations of prevalence and incidence of DM with long-term exposure to air pollution as estimated using annual average concentrations of particulate matter with an aerodynamic diameter of 2.5 μm or less (PM₂.₅) and nitrogen oxides at baseline (2000) in the Multi-Ethnic Study of Atherosclerosis. All participants were aged 45-84 years at baseline and were recruited from 6 US sites. There were 5,839 participants included in the study of prevalent DM and 5,135 participants without DM at baseline in whom we studied incident DM. After adjustment for potential confounders, we found significant associations of prevalent DM with PM₂.₅ (odds ratio (OR) = 1.09, 95% confidence interval (CI): 1.00, 1.17) and nitrogen oxides (OR = 1.18, 95% CI: 1.01, 1.38) per each interquartile-range increase (2.43 µg/m(3) and 47.1 ppb, respectively). Larger but nonsignificant associations were observed after further adjustment for study site (for PM₂.₅, OR = 1.16, 95% CI: 0.94, 1.42; for nitrogen oxides, OR = 1.29, 95% CI: 0.94, 1.76). No air pollution measures were significantly associated with incident DM over the course of the 9-year follow-up period. Results were partly consistent with a link between long-term exposure to air pollution and the risk of type 2 DM. Additional studies with a longer follow-up time and a greater range of air pollution exposures, including high levels, are warranted to evaluate the hypothesized association.
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Details
- Title
- Long-term exposure to air pollution and type 2 diabetes mellitus in a multiethnic cohort
- Creators
- Sung Kyun ParkSara D AdarMarie S O'NeillAmy H AuchinclossAdam SzpiroAlain G BertoniAna Navas-AcienJoel D KaufmanAna V Diez-Roux
- Publication Details
- American journal of epidemiology, v 181(5), pp 327-336
- Publisher
- Oxford University Press; United States
- Grant note
- N01HC95169 / NHLBI NIH HHS UL1-TR-000040 / NCATS NIH HHS N01HC95161 / NHLBI NIH HHS K01-ES016587 / NIEHS NIH HHS N01HC95164 / NHLBI NIH HHS P30 DK092926 / NIDDK NIH HHS N01-HC-95169 / NHLBI NIH HHS N01HC95167 / NHLBI NIH HHS K01 ES016587 / NIEHS NIH HHS N01HC95159 / NHLBI NIH HHS N01-HC-95166 / NHLBI NIH HHS N01HC95163 / NHLBI NIH HHS N01HC95166 / NHLBI NIH HHS N01-HC-95163 / NHLBI NIH HHS K24 ES013195 / NIEHS NIH HHS UL1 RR025005 / NCRR NIH HHS N01-HC-95168 / NHLBI NIH HHS N01-HC-95165 / NHLBI NIH HHS UL1-RR-025005 / NCRR NIH HHS N01-HC-95160 / NHLBI NIH HHS N01HC95160 / NHLBI NIH HHS N01-HC-95162 / NHLBI NIH HHS P30 DK020572 / NIDDK NIH HHS N01-HC-95159 / NHLBI NIH HHS N01HC95168 / NHLBI NIH HHS UL1 TR000040 / NCATS NIH HHS N01-HC-95161 / NHLBI NIH HHS N01-HC-95164 / NHLBI NIH HHS N01HC95165 / NHLBI NIH HHS N01HC95162 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000351507100007
- Scopus ID
- 2-s2.0-84924528913
- Other Identifier
- 991014877825704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health