Journal article
Long-term exposure to ambient particulate matter and prevalence of subclinical atherosclerosis in the multi-ethnic study of atherosclerosis
American journal of epidemiology, v 167(6), pp 667-675
15 Mar 2008
PMID: 18227099
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Exposure to airborne particulate matter has been linked to cardiovascular events. Whether this finding reflects an effect of particulate matter exposure on the triggering of events or development of atherosclerosis remains unknown. Using data from the Multi-Ethnic Study of Atherosclerosis collected at baseline (2000-2002), the authors investigated associations of 20-year exposures to particulate matter with measures of subclinical disease (coronary calcium, common carotid intimal-medial thickness, and ankle-brachial index) in 5,172 US adults without clinical cardiovascular disease. Particulate matter exposures for the 20 years prior to assessment of subclinical disease were obtained from a space-time model of Environmental Protection Agency monitor data linked to residential history data for each participant. Intimal-medial thickness was weakly, positively associated with exposures to particulate matter < 10 mu m in aerodynamic diameter and < 2.5 mu m in aerodynamic diameter after controlling for age, sex, race/ethnicity, socioeconomic factors, diet, smoking, physical activity, blood lipids, diabetes, hypertension, and body mass index (1-4% increase per 21-mu g/m(3) increase in particulate matter < 10 mu m in aerodynamic diameter or a 12.5-mu g/m(3) increase in particulate matter < 2.5 mu m in aerodynamic diameter). No consistent associations with other measures of atherosclerosis were observed. There was no evidence of effect modification by sociodemographic factors, lipid status, smoking, diabetes, body mass index, or site. Results are compatible with some effect of particulate matter exposures on development of carotid atherosclerosis.
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Details
- Title
- Long-term exposure to ambient particulate matter and prevalence of subclinical atherosclerosis in the multi-ethnic study of atherosclerosis
- Creators
- Ana V. Diez Roux - University of MichiganAmy H. Auchincloss - University of MichiganTracy Green Franklin - University of MichiganTrivellore Raghunathan - University of MichiganR. Graham Barr - Columbia University Irving Medical CenterJoel Kaufman - University of WashingtonBrad Astor - University of Wisconsin–MadisonJerry Keeler - Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI 48104 USA
- Publication Details
- American journal of epidemiology, v 167(6), pp 667-675
- Publisher
- Oxford University Press
- Number of pages
- 9
- Grant note
- K24ES013195 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) K24 ES013195-03; K24 ES013195-01A1; K24 ES013195; K24 ES013195-02 / NIEHS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) N01-HC-95159; N01-HC-95165; N01-HC-95169 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) N01HC095169 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000254293200006
- Scopus ID
- 2-s2.0-41149158576
- Other Identifier
- 991014878270304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health