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Journal article
Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc
Science translational medicine, v 10(468), eaau0670
21 Nov 2018
PMID: 30463917
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Tissue engineering holds great promise for the treatment of advanced intervertebral disc degeneration. However, assessment of in vivo integration and mechanical function of tissue-engineered disc replacements over the long term, in large animal models, will be necessary to advance clinical translation. To that end, we developed tissue-engineered, endplate-modified disc-like angle ply structures (eDAPS) sized for the rat caudal and goat cervical spines that recapitulate the hierarchical structure of the native disc. Here, we demonstrate functional maturation and integration of these eDAPS in a rat caudal disc replacement model, with compressive mechanical properties reaching native values after 20 weeks in vivo and evidence of functional integration under physiological loads. To further this therapy toward clinical translation, we implanted eDAPS sized for the human cervical disc space in a goat cervical disc replacement model. Our results demonstrate maintenance of eDAPS composition and structure up to 8 weeks in vivo in the goat cervical disc space and maturation of compressive mechanical properties to match native levels. These results demonstrate the translational feasibility of disc replacement with a tissue-engineered construct for the treatment of advanced disc degeneration.
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Details
- Title
- Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc
- Creators
- Sarah E Gullbrand - University of PennsylvaniaBeth G Ashinsky - School of Biomedical Sciences, Drexel University, Philadelphia, PA 19104, USAEdward D Bonnevie - University of PennsylvaniaDong Hwa Kim - University of PennsylvaniaJulie B Engiles - Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19348, USALachlan J Smith - University of PennsylvaniaDawn M Elliott - University of PennsylvaniaThomas P Schaer - University of PennsylvaniaHarvey E Smith - Philadelphia VA Medical CenterRobert L Mauck - California University of Pennsylvania
- Publication Details
- Science translational medicine, v 10(468), eaau0670
- Publisher
- American Association for the Advancement of Science (AAAS)
- Grant note
- IK2 RX001476 / RRD VA I01 RX001321 / RRD VA F32 AR072478 / NIAMS NIH HHS IK1 RX002445 / RRD VA P30 AR069619 / NIAMS NIH HHS I01 RX002274 / RRD VA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000451464300004
- Scopus ID
- 2-s2.0-85056913896
- Other Identifier
- 991021864307404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Medicine, Research & Experimental