Journal article
Long term outcomes following surgery for pineal region tumors
Journal of neuro-oncology, v 156(3), pp 491-498
01 Feb 2022
PMID: 35083579
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose Pineal region tumors are surgically demanding tumors to resect. Long term neuro-oncologic outcomes following surgical excision of tumors from this region have been underreported. We sought to define the long term outcomes of patients undergoing resection of pineal region tumors. Methods A retrospective analysis of a prospectively maintained database was performed on patients who underwent intended surgical excision of pineal region tumors. Overall survival (OS) and progression free survival (PFS) were the primary endpoints of this study. Factors associated with OS, PFS and the degree of resection were analyzed, along with 30-day complication rates and dependence on CSF diversion. Results Sixty-eight patients with a mean age of 30.9 +/- 15.3 years were analyzed. The median clinical and radiographic follow-up was 95.7 and 48.2 months, respectively. The supracerebellar infratentorial and the occipital transtentorial corridors were utilized in the majority of cases (80.9%). The gross total resection (GTR) rate was 52.9% (n=36). The 5-year OS and PFS rates were 70.2% and 58.5%, respectively. Achieving GTR was associated with improved OS (HR 0.39, p = 0.03) and PFS (HR 0.4, p = 0.006). The 30-day mortality rate was 5.9%. The need for CSF diversion was high with 77.9% of patients requiring a shunt or ETV by last follow-up. Conclusions This is the first modern surgical series providing long term follow-up for patients undergoing surgical resection of pineal region tumors. Obtaining a GTR of these challenging tumors is beneficial with regards to PFS/OS. Higher grade tumors have diminished PFS/OS and are treated with adjuvant chemotherapy and/or radiotherapy.
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Details
- Title
- Long term outcomes following surgery for pineal region tumors
- Creators
- Matthew J. Shepard - Allegheny Health NetworkAli S. Haider - The University of Texas MD Anderson Cancer CenterSujit S. Prabhu - The University of Texas MD Anderson Cancer CenterRaymond Sawaya - The University of Texas MD Anderson Cancer CenterFranco DeMonte - The University of Texas MD Anderson Cancer CenterIan E. McCutcheon - The University of Texas MD Anderson Cancer CenterJeffrey S. Weinberg - The University of Texas MD Anderson Cancer CenterSherise D. Ferguson - The University of Texas MD Anderson Cancer CenterDima Suki - The University of Texas MD Anderson Cancer CenterGregory N. Fuller - The University of Texas MD Anderson Cancer CenterFrederick F. Lang - The University of Texas MD Anderson Cancer Center
- Publication Details
- Journal of neuro-oncology, v 156(3), pp 491-498
- Publisher
- Springer Nature
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000748671200002
- Scopus ID
- 2-s2.0-85123574155
- Other Identifier
- 991022154806504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Oncology