Journal article
Long-term residential exposure to urban air pollution, and repeated measures of systemic blood markers of inflammation and coagulation
Occupational and environmental medicine (London, England), v 72(9), pp 656-663
01 Sep 2015
PMID: 26163546
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background In several studies, exposure to fine particulate matter (PM) has been associated with inflammation, with inconsistent results. We used repeated measurements to examine the association of long-term fine and ultrafine particle exposure with several blood markers of inflammation and coagulation.
Methods We used baseline (2000-2003) and follow-up (2006-2008) data from the Heinz Nixdorf Recall Study, a German population-based prospective cohort of 4814 participants. A chemistry transport model was applied to model daily surface concentrations of PM air pollutants (PM10, PM2.5) and particle number on a grid of 1 km(2). Applying mixed regression models, we analysed associations of long-term (mean of 365 days prior to blood draw) particle exposure at each participant's residence with the level of high-sensitivity C reactive protein (hs-CRP), fibrinogen, platelet and white cell count (WCC), adjusting for short-term PM exposure (moving averages of 1-7 days), personal characteristics, season, ambient temperature (1-5 days), ozone and time trend.
Results We analysed 6488 observations: 3275 participants with baseline data and 3213 with follow-up data. An increase of 2.4 mu g/m(3) in long-term PM2.5 was associated with an adjusted increase of 5.4% (95% CI 0.6% to 10.5%) in hs-CRP and of 2.3% (95% CI 1.4% to 3.3%) in the platelet count. Fibrinogen and WCC were not associated with long-term particle exposure.
Conclusions In this population-based cohort, we found associations of long-term exposure to PM with markers of inflammation (hs-CRP) and coagulation (platelets). This finding supports the hypothesis that inflammatory processes might contribute to chronic effects of air pollution on cardiovascular disease.
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Details
- Title
- Long-term residential exposure to urban air pollution, and repeated measures of systemic blood markers of inflammation and coagulation
- Creators
- Anja Viehmann - College Station Medical CenterSabine Hertel - College Station Medical CenterKateryna Fuks - Heinrich Heine University DüsseldorfLewin Eisele - College Station Medical CenterSusanne Moebus - College Station Medical CenterStefan Moehlenkamp - Bethanien Hosp Moers, Dept Cardiol, Moers, GermanyMichael Nonnemacher - College Station Medical CenterHermann Jakobs - Rhenish Institute for Environmental ResearchRaimund Erbel - Deutsches Herzzentrum MünchenKarl-Heinz Joeckel - College Station Medical CenterBarbara Hoffmann - Heinrich Heine University DüsseldorfHeinz Nixdorf Recall Investigator
- Publication Details
- Occupational and environmental medicine (London, England), v 72(9), pp 656-663
- Publisher
- Bmj Publishing Group
- Number of pages
- 8
- Grant note
- Heinz Nixdorf Foundation, Essen, Germany JO 170/8-1; HO 3314/2-1 / DFG; German Research Foundation (DFG)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000359590000007
- Scopus ID
- 2-s2.0-84939464914
- Other Identifier
- 991020100209104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health