Journal article
Long-term results of triple-layered small diameter vascular grafts in sheep carotid arteries
Medical engineering & physics, v 85, pp 1-6
Nov 2020
PMID: 33081956
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•Fabrication of triple-layered vascular grafts that mimic native blood vessels.•Graft compliance is regulable and compatible with sheep carotid artery.•Triple-layered vascular grafts are promising as small-diameter vessel replacements.
There is an urgent clinical for small diameter vascular grafts (SDVGs) for use in the treatment of coronary artery disease. Moreover, biodegradable SDVGs are drawing increasing attention because they have the potential to restore vascular function with the degradation of vascular graft and tissue regeneration. In this study, we designed triple-layered SDVGs to mimic the native arterial structure, with each layer contributing its unique porosity to the porous structure. We evaluated triple-layered SDVGs in a sheep carotid arterial replacement model. After implantation for 12 months, two grafts were patent and indicated the feasibility of using grafts in large animals. Nevertheless, it was determined that both grafts formed aneurysms at the proximal end. The prevention of such aneurysms remains a challenge for future investigation.
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Details
- Title
- Long-term results of triple-layered small diameter vascular grafts in sheep carotid arteries
- Creators
- Chengjin Wang - Tsinghua UniversityZhen Li - Tsinghua UniversityLei Zhang - Tsinghua UniversityWei Sun - Drexel UniversityJianye Zhou - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, P.R.China.
- Publication Details
- Medical engineering & physics, v 85, pp 1-6
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000579511600001
- Scopus ID
- 2-s2.0-85091254112
- Other Identifier
- 991019167809904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical