Journal article
Longitudinal Changes in Lens Thickness in Myopic Children Enrolled in the Correction of Myopia Evaluation Trial (COMET)
Current eye research, v 41(4), pp 492-500
02 Apr 2016
PMID: 26079108
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose: To describe longitudinal changes in lens thickness in myopic children in the Correction of Myopia Evaluation Trial (COMET) and to investigate the association between these changes and myopia progression.
Methods: Four-hundred sixty-nine 6 to <12-year-old children with -1.25 to -4.50 D of myopia were enrolled in COMET, a clinical trial comparing single vision lenses (SVLs) versus progressive addition lenses (PALs) for slowing myopia. Children remained in their original lenses for 5 years and then could wear contact lenses, SVLs or PALs. Myopia by cycloplegic autorefraction (Nidek ARK 700A) and ocular components, including lens thickness, by A-scan ultrasound (Sonomed A2500) were measured annually over 11 years. Analyses of lens thickness were based on right eye data from 426 children with refractions fit with Gompertz functions. Longitudinal lens thickness measurements for each participant were fit with a third-degree polynomial function, and average polynomial functions were calculated for three groups of children previously identified based on Gompertz functions: 6-7 years at baseline (n = 40), >= 8 years with progressing myopia (n = 329), and >= 8 years with non-progressing myopia (n = 56). ANOVAs were used for comparing the lens curve-based parameters among the three groups. Associations between lens and Gompertz parameters were assessed using Pearson correlations.
Results: Overall, between 6 and 18 years the lenses thinned and then thickened, with the minimum value of 3.37 +/- 0.15mm reached at 11.56 +/- 2.04 years. The minimum lens thickness did not differ among the three myopia groups (p = 0.09), nor was it correlated with the amount of myopia at lens minimum or amount of final myopia (r's = -0.01 and -0.03, respectively, p's>0.05).
Conclusion: As a similar pattern of change in lens thickness with age was found in all children, whether their myopia progressed or not, these results suggest that the association of lens thinning and thickening with the course of myopia is coincidental rather than causal.
Metrics
Details
- Title
- Longitudinal Changes in Lens Thickness in Myopic Children Enrolled in the Correction of Myopia Evaluation Trial (COMET)
- Creators
- Jane Gwiazda - New England College of OptometryThomas T. Norton - Universidade AbertaWei Hou - Stony Brook UniversityLeslie Hyman - Stony Brook UniversityRuth Manny - University of HoustonCOMET GrpMitchell Scheiman - Pennsylvania College of Optometry (PCO)
- Publication Details
- Current eye research, v 41(4), pp 492-500
- Publisher
- Taylor & Francis
- Number of pages
- 9
- Grant note
- EY11740; 11805; 11756; 11754; 11752; 11755 / NEI/NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) U10EY011756 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000375400100009
- Scopus ID
- 2-s2.0-84939488215
- Other Identifier
- 991021900609404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology