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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Longitudinal modulation of immune system cytokine profile during pregnancy
Cytokine (Philadelphia, Pa.), v 53(2)
2011
PMID: 21123081
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To characterize immune modulation as expressed by cytokine assays at three time-points in human pregnancy.
This is a prospective, longitudinal study of a broad panel of cytokine expression during singleton pregnancies resulting in an uncomplicated, full-term, live births. Peripheral blood was obtained at 8–14, 18–22, and 28–32
weeks gestation. Six cytokines – IFN-γ, IL-4, TNF-α, IL-1β, IL-6, and IL-10 – were measured in supernatants obtained from whole blood stimulations with PHA or LPS and were compared to unstimulated controls. Samples were processed by Luminex-100 MAP®. We used Generalized Linear Models (GLM) to evaluate cytokine trajectories.
Complete data were obtained for 45 uncomplicated pregnancies. Overall, peripheral blood WBC’s demonstrated dampened cytokine responses. However, over the course of pregnancy, we found enhanced counter-regulatory cytokine expression (e.g., shown by increased IL-10).
The overall decrease in pro-inflammatory cytokines and increase in counter-regulatory cytokines as uncomplicated pregnancy progresses supports the evolving concepts of immunoregulation for the maintenance of a viable pregnancy.
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Details
- Title
- Longitudinal modulation of immune system cytokine profile during pregnancy
- Creators
- Jeffrey M. Denney - Children's Hospital of PhiladelphiaEdward L. Nelson - University of California, IrvinePathik D. Wadhwa - University of California, IrvineThaddeus P. Waters - MetroHealthLeny Mathew - Children's Hospital of PhiladelphiaEsther K. Chung - Thomas Jefferson UniversityRobert L. Goldenberg - Drexel UniversityJennifer F. Culhane - University of Pennsylvania
- Publication Details
- Cytokine (Philadelphia, Pa.), v 53(2)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000287272700008
- Scopus ID
- 2-s2.0-78651062585
- Other Identifier
- 991019339569804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Immunology