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Published, Version of Record (VoR)CC BY-NC V4.0, Open
Journal article
Longitudinal neighbourhood determinants with cognitive health and dementia disparities: protocol of the Multi-Ethnic Study of Atherosclerosis Neighborhoods and Aging prospective cohort study
BMJ open, v 12(11), pp e066971-e066971
11 Nov 2022
PMID: 36368762
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
IntroductionThe burden of Alzheimer’s disease (AD) and AD-related dementias (ADRD) is increasing nationally and globally, with disproportionate impacts on lower-income, lower education and systematically marginalised older adults. Presence of inequalities in neighbourhood factors (eg, social context, physical and built environments) may affect risk of cognitive decline and be key for intervening on AD/ADRD disparities at the population level. However, existing studies are limited by a dearth of longitudinal, detailed neighbourhood measures linked to rich, prospective cohort data. Our main objective is to identify patterns of neighbourhood change related to prevalence of—and disparities in—cognitive decline and dementia.Methods and analysesWe describe the process of collecting, processing and linking extensive neighbourhood data to the Multi-Ethnic Study of Atherosclerosis (MESA), creating a 25+ years dataset. Within the MESA parent study, the MESA Neighborhoods and Aging cohort study will characterise dynamic, longitudinal neighbourhood social and built environment variables relevant to cognition for residential addresses of MESA participants. This includes administering new surveys, expanding residential address histories, calculating new measures derived from spatial data and implementing novel deep learning algorithms on street-level imagery. Applying novel statistical techniques, we will examine associations of neighbourhood environmental characteristics with cognition and clinically relevant AD/ADRD outcomes. We will investigate determinants of disparities in outcomes by socioeconomic position and race/ethnicity and assess the contribution of neighbourhood environments to these disparities. This project will provide new evidence about pathways between neighbourhood environments and cognitive outcomes, with implications for policies to support healthy ageing.Ethics and disseminationThis project was approved by the University of Washington and Drexel University Institutional Review Boards (protocols #00009029 and #00014523, and #180900605). Data will be distributed through the MESA Coordinating Center. Findings will be disseminated in peer-reviewed scientific journals, briefs, presentations and on the participant website.
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Details
- Title
- Longitudinal neighbourhood determinants with cognitive health and dementia disparities: protocol of the Multi-Ethnic Study of Atherosclerosis Neighborhoods and Aging prospective cohort study
- Creators
- Jana A Hirsch - Drexel UniversityYvonne L Michael - Drexel UniversityKari A Moore - Drexel UniversitySteven Melly - Drexel UniversityTimothy M Hughes - Department of Internal Medicine, Medical Center Boulevard, Winston-Salem, Carolina, USAKathleen Hayden - Department of Social Sciences and Health Policy, Bowman Gray Center for Medical Education, Winston-Salem, Carolina, USAJose A Luchsinger - Department of Medicine, Columbia University, New York, New York, USAMarcia P Jimenez - Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USAPeter James - Department of Population Medicine, Harvard TH Chan School of Public Health, Boston, Massachusetts, USALilah M Besser - University of MiamiBrisa Sánchez - Drexel UniversityAna V Diez Roux - Drexel University
- Publication Details
- BMJ open, v 12(11), pp e066971-e066971
- Publisher
- British Medical Journal Publishing Group
- Grant note
- UL1-TR-000040; UL1-TR-001079 / National Center for Research Resources (http://dx.doi.org/10.13039/100000097) 52319 / Robert Wood Johnson, Active Living Research Program 5K99AG066949-02; P30AG049638; R01AG054069; R01AG058969; R01AG072634 / National Institute on Aging (http://dx.doi.org/10.13039/100000049) N01-HC-95159; N01-HC-95160; N01-HC-95161; N01-HC-95162; N01-HC-95163; N01-HC-95164; N01-HC-95165; N01-HC-95166; N01-HC-95167; N01-HC-95168; N01-HC-95169; NIH 2R01 HL071759; R01HL127659 / National Heart, Lung, and Blood Institute (http://dx.doi.org/10.13039/100000050)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000885543100003
- Scopus ID
- 2-s2.0-85141717794
- Other Identifier
- 991019288630604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health