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Journal article
Lopinavir-Ritonavir: Effects on Endothelial Cell Function in Healthy Subjects
The Journal of infectious diseases, v 193(11), pp 1516-1519
01 Jun 2006
PMID: 16652279
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To differentiate between the effects that antiretroviral drugs have on the endothelium and the secondary effects that they have on immune function, viral load, and dyslipidemia, 6 non–human immunodeficiency virus–infected human subjects were treated with lopinavir-ritonavir for 1 month and, on the basis of forearm blood flow, the treatment’s effects on endothelial cell function were measured. Surprisingly, after exposure to lopinavir-ritonavir, absolute forearm blood-flow responses to the endothelium-dependent vasodilator, acetylcholine, increased significantly (P=.03), and forearm blood flow decreased to a greater extent during specific inhibition of NO synthase by NG-monomethyl-l-arginine. Thus, in this small cohort of subjects, short-term treatment with lopinavir-ritonavir does not appear to directly promote endothelial cell dysfunction
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Details
- Title
- Lopinavir-Ritonavir: Effects on Endothelial Cell Function in Healthy Subjects
- Creators
- Jessica R. Grubb - National Institute of Allergy and Infectious DiseasesAndré Dejam - National Institute of Diabetes and Digestive and Kidney DiseasesJocelyn Voell - National Institute of Allergy and Infectious DiseasesWilliam C. BlackwelderPeter A. Sklar - Critical Care Medical Department, Clinical Center,Joseph A. Kovacs - Critical Care Medical Department, Clinical Center,Richard O. Cannon - National Heart Lung and Blood InstituteHenry Masur - Critical Care Medical Department, Clinical Center,Mark T. Gladwin - National Heart Lung and Blood Institute
- Publication Details
- The Journal of infectious diseases, v 193(11), pp 1516-1519
- Publisher
- The University of Chicago Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000237246700007
- Scopus ID
- 2-s2.0-33646948875
- Other Identifier
- 991019174757904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology