Journal article
Loss of CD103+ DCs and Mucosal IL-17+ and IL-22+ Lymphocytes is Associated with Mucosal Damage in SIV Infection
Mucosal immunology, v 5(6), pp 646-657
30 May 2012
PMID: 22643849
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
HIV/SIV disease progression is associated with multifocal damage to the GI tract epithelial barrier that correlates with microbial translocation and persistent pathological immune activation but the underlying mechanisms remain unclear. Investigating alterations in mucosal immunity during SIV infection, we found that damage to the colonic epithelial barrier was associated with loss of multiple lineages of IL-17-producing lymphocytes, cells that microarray analysis showed express genes important for enterocyte homeostasis, including IL-22. IL-22-producing lymphocytes were also lost after SIV infection. Potentially explaining coordinate loss of these distinct populations, we also observed loss of CD103+ DCs after SIV infection which associated with loss of IL-17 and IL-22-producing lymphocytes. CD103+ DCs expressed genes associated with promotion of IL-17/IL-22+ cells, and co-culture of CD103+ DCs and naïve T-cells led to increased
IL17A
and
RORc
expression in differentiating T-cells. These results reveal complex interactions between mucosal immune cell subsets providing potential mechanistic insights into mechanisms of mucosal immune dysregulation during HIV/SIV infection, and offer hints for development of novel therapeutic strategies to address this aspect of AIDS virus pathogenesis.
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Details
- Title
- Loss of CD103+ DCs and Mucosal IL-17+ and IL-22+ Lymphocytes is Associated with Mucosal Damage in SIV Infection
- Creators
- Nichole R. Klatt - National Institutes of HealthJacob D. Estes - Science Applications International Corporation (United States)Xiaoyong Sun - Vaccine & Gene Therapy Institute of FloridaAlexandra M. Ortiz - Emory UniversityJohn S. Barber - Emory UniversityLevelle D. Harris - National Institutes of HealthBarbara Cervasi - Emory UniversityLauren K. Yokomizo - National Institutes of HealthLi Pan - Vaccine & Gene Therapy Institute of FloridaCarol L. Vinton - National Institutes of HealthBrian Tabb - Science Applications International Corporation (United States)Lauren A. Canary - National Institutes of HealthQue Dang - National Institutes of HealthVanessa M. Hirsch - National Institutes of HealthGalit Alter - Harvard UniversityYasmine Belkaid - National Institutes of HealthJeffrey D. Lifson - Science Applications International Corporation (United States)Guido Silvestri - Emory UniversityJoshua D. Milner - National Institutes of HealthMirko Paiardini - Emory UniversityElias K. Haddad - Emory UniversityJason M. Brenchley - National Institutes of Health
- Publication Details
- Mucosal immunology, v 5(6), pp 646-657
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000310572800007
- Scopus ID
- 2-s2.0-84866555781
- Other Identifier
- 991020111220904721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Immunology