Journal article
Loss of Plakophilin-2 Expression Leads to Decreased Sodium Current and Slower Conduction Velocity in Cultured Cardiac Myocytes
Circulation research, v 105(6), pp 523-U33
11 Sep 2009
PMID: 19661460
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Rationale: Plakophilin-2 (PKP2) is an essential component of the cardiac desmosome. Recent data show that it interacts with other molecules of the intercalated disc. Separate studies show preferential localization of the voltage-gated sodium channel (Na(V)1.5) to this region.
Objective: To establish the association of PKP2 with sodium channels and its role on action potential propagation.
Methods and Results: Biochemical, patch clamp, and optical mapping experiments demonstrate that PKP2 associates with Na(V)1.5, and that knockdown of PKP2 expression alters the properties of the sodium current, and the velocity of action potential propagation in cultured cardiomyocytes.
Conclusions: These results emphasize the importance of intermolecular interactions between proteins relevant to mechanical junctions, and those involved in electric synchrony. Possible relevance to the pathogenesis of arrhythmogenic right ventricular cardiomyopathy is discussed. ( Circ Res. 2009; 105: 523-526.)
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Details
- Title
- Loss of Plakophilin-2 Expression Leads to Decreased Sodium Current and Slower Conduction Velocity in Cultured Cardiac Myocytes
- Creators
- Priscila Y. Sato - University of MichiganHassan Musa - University of MichiganWanda Coombs - University at Albany, State University of New YorkGuadalupe Guerrero-Serna - University of MichiganGustavo A. Patino - University of MichiganSteven M. Taffet - University at Albany, State University of New YorkLori L. Isom - College Station Medical CenterMario Delmar - University of Michigan
- Publication Details
- Circulation research, v 105(6), pp 523-U33
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 16
- Grant note
- R01MH059980 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01GM057691 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) GM057691-12; HL039707; HL087226; MH 059980 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P01HL039707 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000269711900002
- Scopus ID
- 2-s2.0-70349242035
- Other Identifier
- 991020100084204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Hematology
- Peripheral Vascular Disease