Files and links (1)
article-loss-2019-OfocheU863.03 kB
Published, Version of Record (VoR)available upon request Restricted Access
Journal article
Loss of consciousness and altered mental state predicting depressive and post-concussive symptoms after mild traumatic brain injury
Brain injury, v 33(8), pp 1064-1069
03 Jul 2019
PMID: 31017017
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: Limited studies exist on the association between loss of consciousness (LOC) and altered mental state (AMS) and development of depressive and post-concussive symptoms within six months after mild traumatic brain injury (mTBI). We tested the hypothesis that presence of Objective: Limited studies exist on the association between loss of consciousness (LOC) and altered mental state (AMS) and development of depressive and post-concussive symptoms within six months after mild traumatic brain injury (mTBI). We tested the hypothesis that presence of both LOC and AMS predict the highest risk of symptoms within the first six months post-mTBI compared to either variable alone, and that LOC alone is more strongly associated with these symptoms.
Research design: We analyzed data from 407 subjects with mTBI from the Head injury Serum Markers for Assessing Response to Trauma (HeadSMART) cohort, a prospective cohort of patients post-TBI presenting to two urban emergency departments.
Results: There were higher rates of depressive (44%) and post-concussive symptoms (54%) at 1 month post-injury, among participants with both LOC and AMS compared to other groups. AMS was associated with depressive symptoms at one and six months (OR = 1.59, p = .038; OR = 1.60; p = .060) and post-concussive symptoms at one month (OR = 1.56, p = .053). LOC was associated only with post-concussive symptoms at one month (OR = 1.55;p = .048). Among those without LOC, AMS was associated with depressive symptoms at one month (OR = 2.24; p = .028).
Conclusions: AMS predicts post-mTBI depressive symptoms both in the acute and chronic mTBI phases whereas LOC is a more sensitive predictor of post-concussive symptoms in the acute mTBI period.
Metrics
Details
- Title
- Loss of consciousness and altered mental state predicting depressive and post-concussive symptoms after mild traumatic brain injury
- Creators
- Durga Roy - Johns Hopkins MedicineMatthew E. Peters - Johns Hopkins UniversityAllen Everett - Johns Hopkins UniversityJeannie-Marie Leoutsakos - Johns Hopkins UniversityHaijuan Yan - Johns Hopkins MedicineVani Rao - Johns Hopkins MedicineKathleen Bechtold - Johns Hopkins MedicineHaris Sair - Johns Hopkins MedicineTimothy E. Van Meter - Program for Neurological Diseases, ImmunArray IncHayley Falk - University of MichiganAlexandra Vassila - Theradex OncologyAnna Hall - Johns Hopkins MedicineUju Ofoche - Drexel UniversityFreshta Akbari - University of Maryland, BaltimoreConstantine G. Lyketsos - Jefferson College of Health SciencesFredrick Korley - University of Michigan Medical School
- Publication Details
- Brain injury, v 33(8), pp 1064-1069
- Publisher
- Taylor & Francis
- Number of pages
- 6
- Grant note
- Immunarray USA, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000470441500001
- Scopus ID
- 2-s2.0-85065077912
- Other Identifier
- 991021860714004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Rehabilitation