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Loss of synaptophysin immunoexpression in primary progressive aphasia
Journal article   Open access   Peer reviewed

Loss of synaptophysin immunoexpression in primary progressive aphasia

Carol F Lippa and Andrea L Rosso
American journal of Alzheimer's disease and other dementias, v 27(4)
Jun 2012
PMID: 22586262
url
https://doi.org/10.1177/1533317512446187View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze) Open

Abstract

Aged Fatal Outcome Frontal Lobe - pathology Humans Immunohistochemistry Male Primary Progressive Nonfluent Aphasia - pathology Synapses - pathology Synaptophysin - analysis Synaptophysin - metabolism
Primary progressive aphasia (PPA) is characterized by progressive loss of language, unassociated with generalized cognitive loss and with no uniform pathological abnormality. To address whether the issue of PPA is associated with synaptic loss, we compared immunoreactivity in Broca's area with that in the adjacent gyrus from a case of progressive, nonfluent PPA using antibodies against synaptophysin. Using semiautomated methods, we assessed serial 0.10 mm(2) diameter areas from the cortical surface to the white matter in both the case and the control. In PPA, synaptophysin immunoreactivity was significantly less in Broca's area than in the adjacent area (optical densities of 0.16 and 0.24). The reduced synaptophysin immunoreactivity was significantly greater in the upper cortex than in the regions of cortex adjacent to the white matter (mean optical densities of 0.14 and 0.18). These data suggest that synaptic loss may be a factor underlying the language deficits in PPA.

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Web of Science research areas
Clinical Neurology
Geriatrics & Gerontology
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