Journal article
Low Glycated Hemoglobin and Liver Disease in the US Population
Diabetes care, v 34(12), pp 2548-2550
01 Dec 2011
PMID: 21953797
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
OBJECTIVE-To characterize the association of low HbA(1c) values (<4.0%) with liver enzymes and steatosis.
RESEARCH DESIGN AND METHODS-Cross-sectional study of 12,533 participants without diabetes aged <20 years in the Third National Health and Nutrition Examination Survey (1988-1994). Logistic regression models were adjusted for demographic, lifestyle, and health status variables.
RESULTS-HbA(1c) values ranged from 3.2 to 15.7%, and 84 participants had HbA(1c) <4.0% in the population (mean age 44, 52% female, 15% black or Hispanic). We observed J-shaped associations between HbA(1c) and liver enzymes and hepatic steatosis. In adjusted models, HbA(1c) <4.0% was strongly associated with elevated alanine aminotransferase (OR 3.62 [95% Cl 1.09-12.02]) and aspartate aminotransferase (6.80 [2.99-15.43]).
CONCLUSIONS-Low HbA(1c) values were associated with liver enzymes and steatosis in the U.S. population. Liver disease may partially explain the association of HbA(1c) with mortality and other long-term outcomes.
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Details
- Title
- Low Glycated Hemoglobin and Liver Disease in the US Population
- Creators
- Andrea L. Christman - Johns Hopkins UniversityMariana Lazo - Johns Hopkins UniversityJeanne M. Clark - Johns Hopkins UniversityElizabeth Selvin - Johns Hopkins University
- Publication Details
- Diabetes care, v 34(12), pp 2548-2550
- Publisher
- Amer Diabetes Assoc
- Number of pages
- 3
- Grant note
- R01DK083393 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) T32-DK-062707; R01-DK-083393; K01-DK-076595; R01-DK-089174 / National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) American Diabetes Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000298122900013
- Scopus ID
- 2-s2.0-84860711408
- Other Identifier
- 991020550341304721
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- Web of Science research areas
- Endocrinology & Metabolism