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Journal article
Low-Intensity Ultrasound-Induced Anti-inflammatory Effects Are Mediated by Several New Mechanisms Including Gene Induction, Immunosuppressor Cell Promotion, and Enhancement of Exosome Biogenesis and Docking
Frontiers in physiology, v 8, pp 818-818
23 Oct 2017
PMID: 29109687
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background:
Low-intensity ultrasound (LIUS) was shown to be beneficial in mitigating inflammation and facilitating tissue repair in various pathologies. Determination of the molecular mechanisms underlying the anti-inflammatory effects of LIUS allows to optimize this technique as a therapy for the treatment of malignancies and aseptic inflammatory disorders.
Methods:
We conducted cutting-edge database mining approaches to determine the anti-inflammatory mechanisms exerted by LIUS.
Results:
Our data revealed following interesting findings: (1) LIUS anti-inflammatory effects are mediated by upregulating anti-inflammatory gene expression; (2) LIUS induces the upregulation of the markers and master regulators of immunosuppressor cells including MDSCs (myeloid-derived suppressor cells), MSCs (mesenchymal stem cells), B1-B cells and Treg (regulatory T cells); (3) LIUS not only can be used as a therapeutic approach to deliver drugs packed in various structures such as nanobeads, nanospheres, polymer microspheres, and lipidosomes, but also can make use of natural membrane vesicles as small as exosomes derived from immunosuppressor cells as a novel mechanism to fulfill its anti-inflammatory effects; (4) LIUS upregulates the expression of extracellular vesicle/exosome biogenesis mediators and docking mediators; (5) Exosome-carried anti-inflammatory cytokines and anti-inflammatory microRNAs inhibit inflammation of target cells via multiple shared and specific pathways, suggesting exosome-mediated anti-inflammatory effect of LIUS feasible; and (6) LIUS-mediated physical effects on tissues may activate specific cellular sensors that activate downstream transcription factors and signaling pathways.
Conclusions:
Our results have provided novel insights into the mechanisms underlying anti-inflammatory effects of LIUS, and have provided guidance for the development of future novel therapeutic LIUS for cancers, inflammatory disorders, tissue regeneration and tissue repair.
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Details
- Title
- Low-Intensity Ultrasound-Induced Anti-inflammatory Effects Are Mediated by Several New Mechanisms Including Gene Induction, Immunosuppressor Cell Promotion, and Enhancement of Exosome Biogenesis and Docking
- Creators
- Qian Yang - , , , , , , , , , , , ,Gayani K. Nanayakkara - Temple UniversityCharles Drummer - Temple UniversityYu Sun - Temple UniversityCandice Johnson - Temple UniversityRamon Cueto - Temple UniversityHangfei Fu - Temple UniversityYing Shao - Temple UniversityLuqiao Wang - First Affiliated Hospital of Kunming Medical UniversityWilliam Y. Yang - Temple UniversityPeng Tang - China Rehabilitation Research CenterLi-Wen Liu - , , , , , , , , , , , ,Shuping Ge - St. Christopher's Hospital for ChildrenXiao-Dong Zhou - , , , , , , , , , , , ,Mohsin Khan - Temple UniversityHong Wang - Temple UniversityXiaofeng Yang - Temple University
- Publication Details
- Frontiers in physiology, v 8, pp 818-818
- Publisher
- Frontiers Media S.A
- Grant note
- RO1 - HL132399-01A1 / Foundation for the National Institutes of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000413426500001
- Scopus ID
- 2-s2.0-85032220542
- Other Identifier
- 991019167687304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Physiology