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Journal article
Low Levels of Circulating Adiponectin Are Associated with Multiple Myeloma Risk in Overweight and Obese Individuals
Cancer research (Chicago, Ill.), v 76(7), pp 1935-1941
01 Apr 2016
PMID: 26921332
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The association between obesity and multiple myeloma risk may be partly attributed to reduced circulating levels of adiponectin in obese individuals. To prospectively evaluate multiple myeloma risk in relation to adiponectin levels overall and stratified by body mass index and other characteristics, we conducted a pooled investigation of pre-diagnosed peripheral blood samples from 624 multiple myeloma cases and 1,246 individually matched controls from seven cohorts participating in the Multiple Myeloma Cohort Consortium. Analysis of circulating analyte levels measured by ELISA revealed that higher total adiponectin levels were associated with reduced multiple myeloma risk overall [highest quartile vs. lowest: OR, 0.64; 95% confidence interval (CI) 0.47-0.85; Ptrend = 0.001]. This association was apparent among cases diagnosed six or more years after blood collection (OR, 0.60; 95% CI, 0.40-0.90; Ptrend = 0.004) and was similar in magnitude for men and women (OR, 0.59 and 0.66, respectively). Interestingly, we observed strong associations among subjects who were overweight (OR, 0.41; 95% CI, 0.26-0.65) or obese (OR, 0.41; 95% CI, 0.17-0.98) but not among those with normal weight (OR, 1.20; 95% CI, 0.73-2.00; overweight/obese vs. normal weight, Pinteraction = 0.04). Our findings provide the strongest epidemiologic evidence to date that adiponectin protects against multiple myeloma development, particularly among overweight and obese individuals, and offer a method for risk assessment in this susceptible population of heavier patients. Cancer Res; 76(7); 1935-41. ©2016 AACR.
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Details
- Title
- Low Levels of Circulating Adiponectin Are Associated with Multiple Myeloma Risk in Overweight and Obese Individuals
- Creators
- Jonathan N Hofmann - National Cancer InstituteBrenda M Birmann - Brigham and Women's HospitalLauren R Teras - American Cancer SocietyRuth M Pfeiffer - National Cancer InstituteYe Wang - Jewish General HospitalDemetrius Albanes - National Cancer InstituteDalsu Baris - National Cancer InstituteGraham A Colditz - Jewish HospitalAnneclaire J De Roos - Drexel UniversityGraham G Giles - Cancer Council VictoriaH Dean Hosgood - Albert Einstein College of MedicineQing Lan - National Cancer InstituteOla Landgren - Memorial Sloan Kettering Cancer CenterLinda M Liao - National Cancer InstituteNathaniel Rothman - National Cancer InstituteStephanie J Weinstein - National Cancer InstituteMichael N Pollak - Jewish General HospitalMarian L Neuhouser - Fred Hutchinson Cancer Research CenterMark P Purdue - National Cancer Institute
- Publication Details
- Cancer research (Chicago, Ill.), v 76(7), pp 1935-1941
- Publisher
- American Association for Cancer Research (AACR)
- Grant note
- UM1 CA167552 / NCI NIH HHS HHSN268201100002I / NHLBI NIH HHS HHSN271201100004C / NIA NIH HHS HHSN268201100001C / WHI NIH HHS HHSN268201100004I / NHLBI NIH HHS Z01 CP010136-12 / Intramural NIH HHS P01 CA087969 / NCI NIH HHS UM1 CA186107 / NCI NIH HHS K07 CA115687 / NCI NIH HHS HHSN268201100004C / WHI NIH HHS HHSN268201100046C / NHLBI NIH HHS R01 CA149445 / NCI NIH HHS HHSN268201100002C / WHI NIH HHS HHSN268201100001I / NHLBI NIH HHS R01 CA127435 / NCI NIH HHS R01 CA049449 / NCI NIH HHS ZIA CP010136-14 / Intramural NIH HHS HHSN268201100003C / WHI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000374169600028
- Scopus ID
- 2-s2.0-84963768563
- Other Identifier
- 991019168188104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology