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Journal article
Low Social Support Is Associated With Shorter Leukocyte Telomere Length in Late Life: Multi-Ethnic Study of Atherosclerosis
Psychosomatic medicine, v 75(2), pp 171-177
01 Feb 2013
PMID: 23370895
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: The primary goal was to test the hypothesis that limited social support (SS) is related to shorter leukocyte telomere length (LTL), particularly in an older adult population. Methods: Cross-sectional analyses were performed on 948 participants aged 45 to 84 years at Examination 1 of the Multi-Ethnic Study of Atherosclerosis (18.4% white, 53.1% Hispanics, and 28.5% African American). LTL was determined by using quantitative polymerase chain reaction, and SS was measured with the Enhancing Recovery in Coronary Heart Disease SS inventory. Results: Across the entire sample, SS was not associated with LTL (p = .87) after adjusting for demographic (age, sex, race/ethnicity, socioeconomic status), age x sex, age x race, health (body mass index, diabetes, pulse pressure), and life-style factors (smoking, physical activity, diet); however, the interaction term age (dichotomized) x SS was significant (p = .001). Stratification by age group revealed a positive association between SS (score range, 5-25) and LTL in the older (65-84 years; B[SE] = .005[.002]; p = .007) but not younger participants (45-64 years; p = .12) after adjusting for covariates. Conclusions: These results from a racially/ethnically diverse community sample of men and women provide initial evidence that low SS is associated with shorter LTL in adults aged 65 years and older and is consistent with the hypothesis that social environment may contribute to rates of cellular aging, particularly in late life.
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Details
- Title
- Low Social Support Is Associated With Shorter Leukocyte Telomere Length in Late Life: Multi-Ethnic Study of Atherosclerosis
- Creators
- Judith E. Carroll - College Station Medical CenterAna V. Diez Roux - University of MichiganAnnette L. Fitzpatrick - University of WashingtonTeresa Seeman - Institute of Neuroimmunology of the Slovak Academy of Sciences
- Publication Details
- Psychosomatic medicine, v 75(2), pp 171-177
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Grant note
- P30AG017265 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01HL101161 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Cousins Center for Psychoneuroimmunology, University of California, Los Angeles; University of California System R01 HL101161; N01-HC 95159; N01-HC 95160; N01-HC 95161; N01-HC 95162; N01-HC 95163; N01-HC 95164; N01-HC 95165; N01-HC 95166; N01-HC 95167; N01-HC 95168; N01-HC 95169 / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) T32MH019925 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) T32-MH19925 / National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) N01HC095169 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Drexel University
- Web of Science ID
- WOS:000330466400009
- Scopus ID
- 2-s2.0-84873998612
- Other Identifier
- 991020112026404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry
- Psychology
- Psychology, Multidisciplinary