Journal article
Low density lipoprotein (LDL) inhibits histamine release from human mast cells
Biochemical and biophysical research communications, v 148(2), pp 553-559
29 Oct 1987
PMID: 2446600
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We examined the effect of low density lipoprotein (LDL) on histamine release from purified human lung mast cells. LDL inhibited anti-IgE- induced histamine release in a dose-dependent manner, with 100μg/ml LDL-protein inhibiting histamine release by 83±8% (mean±SEM); half-maximal inhibition occurred at 40–80 μg/ml. LDL also inhibited calcium ionophore A23187-induced histamine release in a dose-dependent manner, with 1 mg/ml of LDL inhibiting histamine release by 83 ± 9%; half maximal inhibition occurred at 220–280 μ/ml. Inhibition by LDL was time-dependent: half-maximal inhibition of anti-IgE- induced histamine release by LDL occurred at 30–50 minutes of incubation. The inhibitory effect of LDL was independent of buffer calcium concentrations (0–5 mM) or temperature (0–37°C). These data are consistent with a newly defined immunoregulatory role for LDL.
Metrics
Details
- Title
- Low density lipoprotein (LDL) inhibits histamine release from human mast cells
- Creators
- Edward S. Schulman - Jefferson College of Health SciencesThomas J. Quinn - Jefferson CollegeThomas J. Post - Jefferson CollegePhillip O'Donnell - Jefferson CollegeAnnabelle Rodriguez - Jefferson CollegeBoas Gonen - Jefferson College
- Publication Details
- Biochemical and biophysical research communications, v 148(2), pp 553-559
- Publisher
- Elsevier
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pulmonary, Critical Care, and Sleep (Medicine)
- Web of Science ID
- WOS:A1987K563000006
- Scopus ID
- 2-s2.0-0023232765
- Other Identifier
- 991021934994004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics