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Low dietary magnesium intake alters vitamin D—parathyroid hormone relationship in adults who are overweight or obese
Journal article   Peer reviewed

Low dietary magnesium intake alters vitamin D—parathyroid hormone relationship in adults who are overweight or obese

May M. Cheung, Rosemary DeLuccia, Rohit Kumar Ramadoss, Abeer Aljahdali, Stella L. Volpe, Patricia A. Shewokis and Deeptha Sukumar
Nutrition research (New York, N.Y.), v 69, pp 82-93
Sep 2019
DOI: https://doi.org/10.1016/j.nutres.2019.08.003
PMID: 31675537
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Cardiovascular health Magnesium Parathyroid hormone Vitamin D
Vitamin D metabolism is dependent on magnesium (Mg) as a cofactor; therefore, poor Mg status may alter the relationship between vitamin D metabolite serum 25-hydroxyvitamin D (s25OHD) and serum parathyroid hormone (sPTH). We hypothesized that low dietary Mg intake may alter sPTH response to s25OHD in a population with excess body weight, thereby leading to a worsening of cardiometabolic health. To explore this hypothesis, we conducted a cross-sectional study on adults who were either overweight or obese (owt/ob). Dietary Mg intake was measured using a Mg food frequency questionnaire (MgFFQ). Body composition information was measured using Dual Energy X-ray Absorptiometry (DXA). Blood samples were obtained for all biochemical analyses. A total of 57 participants, 22 to 65 years of age, with a body mass index between 25 to 45 kg/m2 were divided into 3 groups, according to dietary Mg intake percentiles (Low Mg Group = <33 percentile, Medium Mg Group = 33 to 66 percentile, High Mg Group = >66 percentile). Higher s25OHD was negatively associated with lower sPTH in the High Mg Intake group (r = −0.472, P = .041), but not in other groups. A positive relationship between s25OHD and serum high-molecular weight adiponectin concentrations was observed in the High Mg Group (r = 0.532, r = 0.022), but not in other groups. Serum Interleukin-6 concentrations were negatively associated with s25OHD (r = −0.316, P = .017) for the entire study group. Based on these results, our study demonstrated that a low dietary Mg intake may alter PTH response to 25OHD.

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Web of Science research areas
Nutrition & Dietetics
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