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Journal article
Low-frequency (< 100 kHz), low-intensity (< 100mW/cm(2)) ultrasound to treat venous ulcers: A human study and in vitro experiments
The Journal of the Acoustical Society of America, v 134(2), pp 1541-1547
01 Aug 2013
PMID: 23927194
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this study was to examine whether low frequency (<100 kHz), low intensity (<100 mW/cm(2), spatial peak temporal peak) ultrasound can be an effective treatment of venous stasis ulcers, which affect 500 000 patients annually costing over $1 billion per year. Twenty subjects were treated with either 20 or 100 kHz ultrasound for between 15 and 45min per session for a maximum of four treatments. Healing was monitored by changes in wound area. Additionally, two in vitro studies were conducted using fibroblasts exposed to 20 kHz ultrasound to confirm the ultrasound's effects on proliferation and cellular metabolism. Subjects receiving 20 kHz ultrasound for 15min showed statistically faster (p < 0.03) rate of wound closure. All five of these subjects fully healed by the fourth treatment session. The in vitro results indicated that 20 kHz ultrasound at 100 mW/cm(2) caused an average of 32% increased metabolism (p < 0.05) and 40% increased cell proliferation (p < 0.01) after 24 h when compared to the control, non-treated cells. Although statistically limited, this work supports the notion that low-intensity, low-frequency ultrasound is beneficial for treating venous ulcers.
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Details
- Title
- Low-frequency (< 100 kHz), low-intensity (< 100mW/cm(2)) ultrasound to treat venous ulcers: A human study and in vitro experiments
- Creators
- Joshua A. Samuels - Drexel UniversityMichael S. Weingarten - Drexel UniversityDavid J. Margolis - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaLeonid Zubkov - Drexel UniversityYouhan Sunny - Drexel UniversityChristopher R. Bawiec - Drexel UniversityDolores Conover - Drexel UniversityPeter A. Lewin - Drexel University
- Publication Details
- The Journal of the Acoustical Society of America, v 134(2), pp 1541-1547
- Publisher
- Acoustical Soc Amer Amer Inst Physics
- Number of pages
- 7
- Grant note
- Calhoun Biomedical Engineering Endowment of Drexel University R01EB009670 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) 5 R01 EB009670 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000322739300012
- Scopus ID
- 2-s2.0-84882296078
- Other Identifier
- 991019168390104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Audiology & Speech-language Pathology