Journal article
Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease
Brain research bulletin, v 71(1)
2006
PMID: 17113940
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1–1.5
Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change
=
0.93
±
0.62; Wilcoxon:
p
=
0.0002,
n
=
13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain–electrode interface.
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Details
- Title
- Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease
- Creators
- A. Priori - Dipartimento di Scienze Neurologiche, Università di Milano, Fondazione IRCCS Ospedale Policlinico, Milano, ItalyG. Ardolino - Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoS. Marceglia - Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoS. Mrakic-Sposta - Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoM. Locatelli - Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoF. Tamma - Ospedale San PaoloL. Rossi - Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoG. Foffani - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Publication Details
- Brain research bulletin, v 71(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000242735500021
- Scopus ID
- 2-s2.0-33750980429
- Other Identifier
- 991019353626004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences