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Journal article
Low intensity, high frequency vibration training to improve musculoskeletal function in a mouse model of volumetric muscle loss
Journal of orthopaedic research, v 43(3), pp 622-631
Mar 2025
PMID: 39610268
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study's objective was to investigate the extent to which two different levels of low-intensity vibration training (0.6 g or 1.0 g) affected musculoskeletal structure and function after a volumetric muscle loss (VML) injury in male C57BL/6J mice. All mice received a unilateral VML injury to the posterior plantar flexors. Mice were randomized into a control group (no vibration; VML-noTX), or one of two experimental groups. The two experimental groups received vibration training for 15-min/day, 5-days/week for 8 weeks at either 0.6 g (VML-0.6 g) or 1.0 g (VML-1.0 g) beginning 3-days after induction of VML. Muscles were analyzed for contractile and metabolic adaptations. Tibial bone mechanical properties and geometric structure were assessed by a three-point bending test and microcomputed tomography (µCT). Body mass-normalized peak isometric-torque was 18% less in VML-0.6 g mice compared with VML-noTx mice (p = 0.030). There were no statistically significant differences of vibration intervention on contractile power or muscle oxygen consumption (p ≥ 0.191). Bone ultimate load, but not stiffness, was ~16% greater in tibias of VML-1.0 g mice compared with those from VML-noTx mice (p = 0.048). Cortical bone volume was ~12% greater in tibias of both vibration groups compared with VML-noTx mice (p = 0.003). Importantly, cross-section moment of inertia, the primary determinant of bone ultimate load, was 44% larger in tibias of VML-0.6 g mice compared with VML-noTx mice (p = 0.006). These changes indicate that following VML, bones are more responsive to the selected vibration training parameters than muscle. Vibration training represents a possible adjuvant intervention to address bone deficits following VML.
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Details
- Title
- Low intensity, high frequency vibration training to improve musculoskeletal function in a mouse model of volumetric muscle loss
- Creators
- Daniel B. Hoffman - University of MinnesotaAlbino G. Schifino - University of GeorgiaMarion A. Cooley - Augusta UniversityRoger X. Zhong - Augusta UniversityJunwon Heo - University of GeorgiaCourtney M. Morris - University of GeorgiaMatthew J. Campbell - University of GeorgiaGordon L. Warren - Georgia State UniversitySarah M. Greising - University of MinnesotaJarrod A. Call - University of Georgia
- Publication Details
- Journal of orthopaedic research, v 43(3), pp 622-631
- Publisher
- John Wiley and Sons Inc
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physical Therapy (and Rehabilitation Sciences)
- Web of Science ID
- WOS:001367025900001
- Scopus ID
- 2-s2.0-85210496117
- Other Identifier
- 991022030046104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Orthopedics