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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior
Nature neuroscience, v 15(10), pp 1356-1358
01 Oct 2012
PMID: 22922785
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The factors underlying vulnerability to alcoholism are largely unknown. We identified in rodents an innate endophenotype predicting individual risk for alcohol-related behaviors that was associated with decreased expression of the neuroplasticity-related polysialylated neural cell adhesion molecule (PSA-NCAM). Depletion of PSA-NCAM in the ventromedial prefrontal cortex was sufficient to render mice unable to extinguish alcohol seeking, indicating a causal role of naturally occurring variation. These data suggest a mechanism of aberrant prefrontal neuroplasticity that underlies enhanced propensity for inflexible addiction-related behavior.
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Details
- Title
- Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior
- Creators
- Jacqueline M. Barker - Yale UniversityMary M. Torregrossa - Connecticut Mental Health CenterJane R. Taylor - Connecticut Mental Health Center
- Publication Details
- Nature neuroscience, v 15(10), pp 1356-1358
- Publisher
- Springer Nature
- Number of pages
- 3
- Grant note
- P50 AA012870; R01 DA011717; F31 AA020135; K01 DA031745 / National Institutes of Health grants; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P50AA012870 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) Connecticut Department of Mental Health and Addiction Services National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) K01DA031745 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000309335300011
- Scopus ID
- 2-s2.0-84866739806
- Other Identifier
- 991020100063604721
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- Web of Science research areas
- Neurosciences