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Journal article
Low-voltage fast seizures in humans begin with increased interneuron firing
Annals of neurology, v 84(4), pp 588-600
Oct 2018
PMID: 30179277
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Intracellular recordings from cells in entorhinal cortex tissue slices show that low-voltage fast (LVF) onset seizures are generated by inhibitory events. Here, we determined whether increased firing of interneurons occurs at the onset of spontaneous mesial-temporal LVF seizures recorded in patients.
The seizure onset zone (SOZ) was identified using visual inspection of the intracranial electroencephalogram. We used wavelet clustering and temporal autocorrelations to characterize changes in single-unit activity during the onset of LVF seizures recorded from microelectrodes in mesial-temporal structures. Action potentials generated by principal neurons and interneurons (ie, putative excitatory and inhibitory neurons) were distinguished using waveform morphology and K-means clustering.
From a total of 200 implanted microelectrodes in 9 patients during 13 seizures, we isolated 202 single units; 140 (69.3%) of these units were located in the SOZ, and 40 (28.57%) of them were classified as inhibitory. The waveforms of both excitatory and inhibitory units remained stable during the LVF epoch (p > > 0.05). In the mesial-temporal SOZ, inhibitory interneurons increased their firing rate during LVF seizure onset (p < 0.01). Excitatory neuron firing rates peaked 10 seconds after the inhibitory neurons (p < 0.01). During LVF spread to the contralateral mesial temporal lobe, an increase in inhibitory neuron firing rate was also observed (p < 0.01).
Our results suggest that seizure generation and spread during spontaneous mesial-temporal LVF onset events in humans may result from increased inhibitory neuron firing that spawns a subsequent increase in excitatory neuron firing and seizure evolution. Ann Neurol 2018;84:588-600.
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Details
- Title
- Low-voltage fast seizures in humans begin with increased interneuron firing
- Creators
- Bahareh Elahian - Department of Electrical and Computer Engineering; University of Memphis; Memphis TNNathan E Lado - Department of Neuroscience Thomas Jefferson University Philadelphia PAEmily Mankin - University of California, Los AngelesSitaram Vangala - University of California, Los AngelesAmrit Misra - Massachusetts General HospitalKaren Moxon - Drexel UniversityItzhak Fried - University of California, Los AngelesAshwini Sharan - Thomas Jefferson UniversityMohammed Yeasin - Department of Electrical and Computer Engineering; University of Memphis; Memphis TNRichard Staba - University of California, Los AngelesAnatol Bragin - University of California, Los AngelesMassimo Avoli - McGill UniversityMichael R Sperling - Thomas Jefferson UniversityJerome Engel, Jr - Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CAShennan A Weiss - Department of Neuroscience Thomas Jefferson University Philadelphia PA
- Publication Details
- Annals of neurology, v 84(4), pp 588-600
- Publisher
- Wiley
- Grant note
- K23 NS094633 / National Institute of Neurological Disorders and Stroke 5K23NS094633-02 / NIH HHS 5R01NS084017-05 / NIH HHS R01 NS033310 / National Institute of Neurological Disorders and Stroke NS033221 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000447367000012
- Scopus ID
- 2-s2.0-85054516315
- Other Identifier
- 991019168563504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences