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Journal article
Lower Quadriceps Rate of Force Development Is Associated With Worsening Physical Function in Adults With or at Risk for Knee Osteoarthritis: 36-Month Follow-Up Data From the Osteoarthritis Initiative
Archives of physical medicine and rehabilitation, v 99(7), pp 1352-1359
01 Jul 2018
PMCID: PMC6019160
PMID: 29408538
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Abstract
Objective: To determine the association between quadriceps rate of force development (RFD) and decline in self-reported physical function and objective measures of physical performance.
Design: Longitudinal cohort study.
Setting: Community-based sample from 4 urban areas.
Participants: Osteoarthritis Initiative participants with or at risk for knee osteoarthritis, who had no history of knee/hip replacement, knee injury, or rheumatoid arthritis (N = 2630).
Interventions: Not applicable.
Main Outcome Measures: Quadriceps RFD (N/s) was measured during isometric strength testing. Worsening physical function was defined as the minimal clinically important difference for worsening self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function subscale score, 20-m walk time, and repeated chair stand time over 36 months.
Results: Compared with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an odds ratio (OR) of .68 (95% confidence interval [C1),.51-.92) after adjustment for age, sex, body mass index, depression, history of chronic diseases, and knee pain. In women, in comparison with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an adjusted OR of .57 (95% CI,.38-.86). This decreased risk did not reach statistical significance in men (OR, 0.81; 95% CI, 0.52-1.27). No statistically significant associations were detected between baseline RFD and walk or chair stand times.
Conclusions: Our results indicate that higher RFD is associated with decreased risk for worsening self-reported physical function but not with decreased risk for worsening of physical performance. (C) 2018 by the American Congress of Rehabilitation Medicine
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Details
- Title
- Lower Quadriceps Rate of Force Development Is Associated With Worsening Physical Function in Adults With or at Risk for Knee Osteoarthritis: 36-Month Follow-Up Data From the Osteoarthritis Initiative
- Creators
- Bo Hu - North China University of Science and TechnologySoren Thorgaard Skou - Univ Southern Denmark, Inst Sports Sci & Clin Biomech, Res Unit Musculoskeletal Funct & Physiotherapy, Odense, DenmarkBarton L. Wise - University of California, DavisGlenn N. Williams - Drexel UniversityMichael. C. Nevitt - University of California, San FranciscoNeil. A. Segal - Department of Rehabilitation Medicine, The University of Kansas, Kansas City, KS(∗).
- Publication Details
- Archives of physical medicine and rehabilitation, v 99(7), pp 1352-1359
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- Pfizer GlaxoSmithKline N01AR022261 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262 / National Institutes of Health, a branch of the Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Novartis Pharmaceuticals Corporation; Novartis Foundation for the National Institutes of Health Merck Research Laboratories; Merck & Company
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physical Therapy (and Rehabilitation Sciences)
- Web of Science ID
- WOS:000437552100013
- Scopus ID
- 2-s2.0-85043230160
- Other Identifier
- 991019168175104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rehabilitation
- Sport Sciences