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Lower Quadriceps Rate of Force Development Is Associated With Worsening Physical Function in Adults With or at Risk for Knee Osteoarthritis: 36-Month Follow-Up Data From the Osteoarthritis Initiative
Journal article   Open access   Peer reviewed

Lower Quadriceps Rate of Force Development Is Associated With Worsening Physical Function in Adults With or at Risk for Knee Osteoarthritis: 36-Month Follow-Up Data From the Osteoarthritis Initiative

Bo Hu, Soren Thorgaard Skou, Barton L. Wise, Glenn N. Williams, Michael. C. Nevitt and Neil. A. Segal
Archives of physical medicine and rehabilitation, v 99(7), pp 1352-1359
01 Jul 2018
DOI: https://doi.org/10.1016/j.apmr.2017.12.027
PMID: 29408538
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.1016/j.apmr.2017.12.027View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

Life Sciences & Biomedicine Rehabilitation Science & Technology Sport Sciences
Objective: To determine the association between quadriceps rate of force development (RFD) and decline in self-reported physical function and objective measures of physical performance. Design: Longitudinal cohort study. Setting: Community-based sample from 4 urban areas. Participants: Osteoarthritis Initiative participants with or at risk for knee osteoarthritis, who had no history of knee/hip replacement, knee injury, or rheumatoid arthritis (N = 2630). Interventions: Not applicable. Main Outcome Measures: Quadriceps RFD (N/s) was measured during isometric strength testing. Worsening physical function was defined as the minimal clinically important difference for worsening self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function subscale score, 20-m walk time, and repeated chair stand time over 36 months. Results: Compared with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an odds ratio (OR) of .68 (95% confidence interval [C1),.51-.92) after adjustment for age, sex, body mass index, depression, history of chronic diseases, and knee pain. In women, in comparison with the slowest tertile of RFD, the fastest tertile had a lower risk for worsening of WOMAC physical function subscale score at 36-month follow-up, with an adjusted OR of .57 (95% CI,.38-.86). This decreased risk did not reach statistical significance in men (OR, 0.81; 95% CI, 0.52-1.27). No statistically significant associations were detected between baseline RFD and walk or chair stand times. Conclusions: Our results indicate that higher RFD is associated with decreased risk for worsening self-reported physical function but not with decreased risk for worsening of physical performance. (C) 2018 by the American Congress of Rehabilitation Medicine

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12 citations in Web of Science
13 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Rehabilitation
Sport Sciences
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