Logo image
Back
Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort
Journal article   Open access   Peer reviewed

Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort

Christine Chew, John A Reynolds, Apinya Lertratanakul, Peggy Wu, Murray Urowitz, Dafna D Gladman, Paul R Fortin, Sang-Cheol Bae, Caroline Gordon, Ann E Clarke, …
Rheumatology (Oxford, England), v 60(10), pp 4737-4747
02 Oct 2021
DOI: https://doi.org/10.1093/rheumatology/keab090
PMID: 33555325
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
http://hdl.handle.net/20.500.12648/8092View
Published, Version of Record (VoR)CC BY-NC-ND V4.0,  Open
url
https://doi.org/10.1093/rheumatology/keab090View
Published, Version of Record (VoR) Open

Abstract

Adult Cohort Studies Cross-Sectional Studies Female Global Health - statistics & numerical data Humans Insulin Resistance Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - complications Male Metabolic Syndrome - epidemiology Metabolic Syndrome - etiology Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin D Deficiency - epidemiology Young Adult
Vitamin D (25(OH)D) deficiency and metabolic syndrome (MetS) may both contribute to increased cardiovascular risk in SLE. We aimed to examine the association of demographic factors, SLE phenotype, therapy and vitamin D levels with MetS and insulin resistance. The Systemic Lupus International Collaborating Clinics (SLICC) enrolled patients recently diagnosed with SLE (<15 months) from 33 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected. Vitamin D level was defined according to tertiles based on distribution across this cohort, which were set at T1 (10-36 nmol/l), T2 (37-60 nmol/l) and T3 (61-174 nmol/l). MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Insulin resistance was determined using the HOMA-IR model. Linear and logistic regressions were used to assess the association of variables with vitamin D levels. Of the 1847 patients, 1163 (63%) had vitamin D measured and 398 (34.2%) subjects were in the lowest 25(OH)D tertile. MetS was present in 286 of 860 (33%) patients whose status could be determined. Patients with lower 25(OH)D were more likely to have MetS and higher HOMA-IR. The MetS components, hypertension, hypertriglyceridemia and decreased high-density lipoprotein (HDL) were all significantly associated with lower 25(OH)D. Increased average glucocorticoid exposure was associated with higher insulin resistance. MetS and insulin resistance are associated with lower vitamin D in patients with SLE. Further studies could determine whether vitamin D repletion confers better control of these cardiovascular risk factors and improve long-term outcomes in SLE.

Metrics

6 Record Views
15 citations in Web of Science
19 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Rheumatology
Logo image