Files and links (2)
Lung Cancer and Exposure to Nitrogen Dioxide and Traffic: A Systematic Review and Meta-Analysis331.90 kB
PDFOpen Access (License Unspecified), Open Access
Journal article
Lung Cancer and Exposure to Nitrogen Dioxide and Traffic: A Systematic Review and Meta-Analysis
Environmental health perspectives, v 123(11), pp 1107-1112
01 Nov 2015
PMID: 25870974
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and objective : Exposure to traffic-related air pol lutants is an important public health issue. Here, we present a systematic review and meta -analysis of research examining the relationship of measures of nitrogen oxides (NOx) and of various measures of traffic related air pollution exposure with lung cancer.
Me thods : We conducted random effects meta -analyses of studies examining exposure to (NO2) and NOx exposure and lung cancer. We identified 20 studies that met inclusion criteria and provided information necessary to estimate the change in lung cancer per 10-mu g/m(3) increase in exposure to measured NO2 . Further, we qualitatively assess the evidence of association between distance to roadways and traffic volume associated with lung cancer.
Results : The meta -estimate for the change in lung cancer associated with a 10-mu g/m(3) increase in exposure to NO2 was 4% (95% CI: 1%, 8%). The meta-estimate for change in lung cancer associated with a 10-mu g/m(3) increase in NOx was similar and slightly more precise, 3% (95% CI: 1%, 5%). The NO2 meta-estimate was robust to different con founding adjustment sets as well as the exposure assessment techniques utilized. Trim-and-fill analyses suggest that if publication bias exists the overall meta -estimate is biased away from the null. Forest plots for measures of traffic volume and distance to roadways largely suggest a modest increase in lung cancer risk.
Conclusion : We found consistent evidence of a relationship between NO2 and NOx, as proxies for traffic sourced air pollution exposure, with lung cancer. Studies of lung cancer related to r esidential proximity to roadways also suggest increased risk, which may be due in p art to air pollution exposure. The International Agency for Research on Cancer recently classified outdoor air pollution and particulate matter as carcinogenic (Group 1). Th ese meta -analyses support this conclusion, drawing particular attention to traffic sourced air pollution
Metrics
Details
- Title
- Lung Cancer and Exposure to Nitrogen Dioxide and Traffic: A Systematic Review and Meta-Analysis
- Creators
- Ghassan B. Hamra - Drexel UniversityFrancine Laden - Harvard UniversityAaron J. Cohen - Health Effects InstituteOle Raaschou-Nielsen - Danish Cancer SocietyMichael Brauer - University of British ColumbiaDana Loomis - Centre international de recherche sur le cancerSarah S Long - Pediatrics
- Publication Details
- Environmental health perspectives, v 123(11), pp 1107-1112
- Publisher
- Us Dept Health Human Sciences Public Health Science
- Number of pages
- 6
- Grant note
- U.S Environment Protection Agency
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000367584600011
- Scopus ID
- 2-s2.0-84946045114
- Other Identifier
- 991019353628704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology