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Lung cancer mortality in a Dutch cohort of asphalt workers: evaluation of possible confounding by smoking
Journal article   Open access   Peer reviewed

Lung cancer mortality in a Dutch cohort of asphalt workers: evaluation of possible confounding by smoking

Mariëtte Hooiveld, Ton Spee, Igor Burstyn, Hans Kromhout and Dick Heederik
American journal of industrial medicine, v 43(1)
Jan 2003
PMID: 12494424
url
https://dspace.library.uu.nl/handle/1874/407103View

Abstract

Smoking - adverse effects Netherlands Occupational Diseases - mortality Confounding Factors (Epidemiology) Lung Neoplasms - mortality Smoking - epidemiology Humans Inhalation Exposure Occupational Exposure Adult Cause of Death Cohort Studies
Using data from a Dutch cohort of workers in road construction and asphalt mixing companies, this article describes possible confounding of the association between exposure to bitumen fume and lung cancer mortality by smoking. A retrospective cohort of 3,714 workers with at least one season of employment was identified. Semi-quantitative exposure to bitumen fume was assessed by a job-exposure matrix. Information on smoking habits was available for a sub-cohort of 1,138 workers, who underwent medical examinations by the occupational health services in the past. Smoking habits differed between occupational title groups and there was a positive association between cumulative exposure and smoking. Internal analyses using the non-exposed subjects as reference category, showed a positive association between semi-quantitative bitumen fume exposure and lung cancer risk. After adjusting for differences in smoking habits, all relative risks were reduced, but a weak positive association could still be observed. Confounding by smoking on the association between exposure to bitumen fume and lung cancer mortality is possible, although the positive trend (not statistically significant) for lung cancer mortality remained. Only a nested case-control study may allow proper treatment of potential (residual) confounding by smoking in this population.

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Public, Environmental & Occupational Health
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