Journal article
Lupus community panel proposals for optimising clinical trials: 2018
Lupus science & medicine, v 5(1), e000258
01 Jan 2018
PMID: 29657738
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Formidable impediments stand in the way of treatment development for lupus. These include the unwieldy size of current trials, international competition for scarce patients, complex outcome measures and a poor understanding of these outcomes in the world at large. The heterogeneity of the disease itself coupled to superimposition of variegated background polypharmacy has created enough immunological noise to virtually ensure the failure of lupus treatment trials, leaving an understandable suspicion that at least some of the results in testing failed drugs over the years may not have been negative, but merely uninterpretable. The authors have consulted with many clinical trial investigators, biopharmaceutical developers and stakeholders from government and voluntary sectors. This paper examines the available evidence that supports workable trial designs and proposes approaches to improve the odds of completing interpretable treatment development programs for lupus.
Metrics
Details
- Title
- Lupus community panel proposals for optimising clinical trials: 2018
- Creators
- Joan T Merrill - Oklahoma Medical Research FoundationSusan Manzi - Allegheny Health NetworkCynthia Aranow - Feinstein Institute for Medical ResearchAnca Askenase - Columbia University Irving Medical CenterIan Bruce - University of ManchesterEliza Chakravarty - Oklahoma Medical Research FoundationBen Chong - The University of Texas Southwestern Medical CenterKaren Costenbader - Brigham and Women's HospitalMaria Dall’Era - City College of San FranciscoEllen Ginzler - SUNY Downstate Health Sciences UniversityLeslie Hanrahan - Lupus Foundation of AmericaKen Kalunian - University of California San DiegoJoseph Merola - Brigham and Women's HospitalSandra Raymond - Lupus Foundation of AmericaBrad Rovin - The Ohio State University Wexner Medical CenterAmit Saxena - New York UniversityVictoria P Werth - University of Pennsylvania
- Publication Details
- Lupus science & medicine, v 5(1), e000258
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000495994400009
- Scopus ID
- 2-s2.0-85048137635
- Other Identifier
- 991021933899204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology