Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Sasha Bernatsky; Hector A. Velasquez Garcia; John J. Spinelli; Patrick Gaffney; Karin E. Smedby; Rosalind Ramsey-Goldman; Sophia S. Wang; Hans-Olov Adami; Demetrius Albanes; Emanuele Angelucci; Stephen M. Ansell; Yan W. Asmann; Nikolaus Becker; Yolanda Benavente; Sonja I. Berndt; Kimberly A. Bertrand; Brenda M. Birmann; Heiner Boeing; Paolo Boffetta; Paige M. Bracci; Paul Brennan; Angela R. Brooks-Wilson; James R. Cerhan; Stephen J. Chanock; Jacqueline Clavel; Lucia Conde; Karen H. Cotenbader; David G. Cox; Wendy Cozen; Simon Crouch; Anneclaire J. De Roos; Silvia de Sanjose; Simonetta Di Lollo; W. Ryan Diver; Ahmet Dogan; Lenka Foretova; Herve Ghesquieres; Graham G. Giles; Bengt Glimelius; Thomas M. Habermann; Corinne Haioun; Patricia Hartge; Henrik Hjalgrim; Theodore R. Holford; Elizabeth A. Holly; Rebecca D. Jackson; Rudolph Kaaks; Eleanor Kane; Rachel S. Kelly; Robert J. Klein; Peter Kraft; Anne Kricker; Qing Lan; Charles Lawrence; Mark Liebow; Tracy Lightfoot; Brian K. Link; Marc Maynadie; James Mckay; Mads Melbye; Thierry J. Molina; Alain Monnereau; Lindsay M. Morton; Alexandra Nieters; Kari E. North; Anne J. Novak; Kenneth Offit; Mark P. Purdue; Marco Rais; Jacques Riby; Eve Roman; Nathaniel Rothman; Gilles Salles; Gianluca Severi; Richard K. Severson; Christine F. Skibola; Susan L. Slager; Alex Smith; Martyn T. Smith; Melissa C. Southey; Anthony Staines; Lauren R. Teras; Carrie A. Thompson; Herve Tilly; Lesley F. Tinker; Anne Tjonneland; Jenny Turner; Claire M. Vajdic; Roel C. H. Vermeulen; Joseph Vijai; Paolo Vineis; Jarmo Virtamo; Zhaoming Wang; Stephanie Weinstein; Thomas E. Witzig; Andrew Zelenetz; Anne Zeleniuch-Jacquotte; Yawei Zhang; Tongzhang Zheng; Mariagrazia Zucca; Ann E. Clarke

doi:10.1136/lupus-2016-000187

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Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

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Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Sasha Bernatsky, Hector A. Velasquez Garcia, John J. Spinelli, Patrick Gaffney, Karin E. Smedby, Rosalind Ramsey-Goldman, Sophia S. Wang, Hans-Olov Adami, Demetrius Albanes, Emanuele Angelucci, …

Lupus science & medicine, v 4(1), pp e000187-e000187

01 Jan 2017

DOI: https://doi.org/10.1136/lupus-2016-000187

PMID: 29214033

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Abstract

Life Sciences & Biomedicine

Rheumatology

Science & Technology

Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.

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Title: Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
Creators: Sasha Bernatsky - McGill University Health Centre
Hector A. Velasquez Garcia - University of British Columbia
John J. Spinelli - University of British Columbia
Patrick Gaffney - Oklahoma Medical Research Foundation
Karin E. Smedby - Karolinska University Hospital
Rosalind Ramsey-Goldman - Northwestern University
Sophia S. Wang - Beckman Research Institute
Hans-Olov Adami - Karolinska Institute
Demetrius Albanes - National Institutes of Health
Emanuele Angelucci - Osped Oncol Riferimento Reg A Businco, Hematol Unit, Cagliari, Italy
Stephen M. Ansell - Mayo Clinic
Yan W. Asmann - Mayo Clinic
Nikolaus Becker - German Cancer Research Center
Yolanda Benavente - Catalan Inst Oncol IDIBELL, Canc Epidemiol Res Programme, Barcelona, Spain
Sonja I. Berndt - National Institutes of Health
Kimberly A. Bertrand - Boston University
Brenda M. Birmann - Brigham and Women's Hospital
Heiner Boeing - German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany
Paolo Boffetta - Icahn School of Medicine at Mount Sinai
Paige M. Bracci - University of California, San Francisco
Paul Brennan - International Agency For Research On Cancer
Angela R. Brooks-Wilson - BC Cancer Agency
James R. Cerhan - Mayo Clinic
Stephen J. Chanock - National Institutes of Health
Jacqueline Clavel - Sorbonne
Lucia Conde - University of Alabama at Birmingham
Karen H. Cotenbader - Brigham and Women's Hospital
David G. Cox - Ctr Leon Berard, INSERM, Canc Res Ctr Lyon, U1052, Lyon, France
Wendy Cozen - University of Southern California
Simon Crouch - University of York
Anneclaire J. De Roos - Drexel University
Silvia de Sanjose - Catalan Inst Oncol IDIBELL, Canc Epidemiol Res Programme, Barcelona, Spain
Simonetta Di Lollo - University of Florence
W. Ryan Diver - American Cancer Society
Ahmet Dogan - Memorial Sloan Kettering Cancer Center
Lenka Foretova - Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic
Herve Ghesquieres - Ctr Leon Berard, Dept Hematol, Lyon, France
Graham G. Giles - University of Melbourne
Bengt Glimelius - Uppsala University
Thomas M. Habermann - Mayo Clinic
Corinne Haioun - Henri Mondor Hosp, Lymphoid Malignancies Unit, Creteil, France
Patricia Hartge - National Institutes of Health
Henrik Hjalgrim - Statens Serum Institut
Theodore R. Holford - Yale University
Elizabeth A. Holly - University of California, San Francisco
Rebecca D. Jackson - The Ohio State University
Rudolph Kaaks - German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany
Eleanor Kane - University of York
Rachel S. Kelly - Brigham and Women's Hospital
Robert J. Klein - Icahn School of Medicine at Mount Sinai
Peter Kraft - Harvard University
Anne Kricker - University of Sydney
Qing Lan - National Institutes of Health
Charles Lawrence - Westat
Mark Liebow - Mayo Clinic
Tracy Lightfoot - University of York
Brian K. Link - Roy J. and Lucille A. Carver College of Medicine
Marc Maynadie - Univ Bourgogne Franche Comte, Registre Hemopathies Malignes Cote Or, EA 4184, Dijon, France
James Mckay - International Agency For Research On Cancer
Mads Melbye - Statens Serum Institut
Thierry J. Molina - Délégation Paris 5
Alain Monnereau - Sorbonne
Lindsay M. Morton - National Institutes of Health
Alexandra Nieters - University Medical Center Freiburg
Kari E. North - University of North Carolina at Chapel Hill
Anne J. Novak - Mayo Clinic
Kenneth Offit - Memorial Sloan Kettering Cancer Center
Mark P. Purdue - Ontario Hlth Study, Toronto, ON, Canada
Marco Rais - University of Cagliari
Jacques Riby - University of Alabama at Birmingham
Eve Roman - University of York
Nathaniel Rothman - National Institutes of Health
Gilles Salles - Hosp Civils Lyon, Dept Hematol, Pierre Benite, France
Gianluca Severi - Human Genet Fdn, Turin, Italy
Richard K. Severson - Wayne State University
Christine F. Skibola - University of Alabama at Birmingham
Susan L. Slager - Mayo Clinic
Alex Smith - University of York
Martyn T. Smith - University of California, Berkeley
Melissa C. Southey - University of Melbourne
Anthony Staines - Dublin City University
Lauren R. Teras - American Cancer Society
Carrie A. Thompson - Mayo Clinic
Herve Tilly - University of Rouen
Lesley F. Tinker - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
Anne Tjonneland - Danish Canc Soc, Res Ctr, Copenhagen, Denmark
Jenny Turner - Macquarie University
Claire M. Vajdic - UNSW Sydney
Roel C. H. Vermeulen - Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands
Joseph Vijai - Memorial Sloan Kettering Cancer Center
Paolo Vineis - Imperial College London
Jarmo Virtamo - Finnish Institute for Health and Welfare
Zhaoming Wang - St. Jude Children's Research Hospital
Stephanie Weinstein - National Institutes of Health
Thomas E. Witzig - Mayo Clinic
Andrew Zelenetz - Memorial Sloan Kettering Cancer Center
Anne Zeleniuch-Jacquotte - New York University
Yawei Zhang - Yale University
Tongzhang Zheng - Brown Sch Publ Hlth, Dept Epidemiol, Providence, RI USA
Mariagrazia Zucca - University of Cagliari
Ann E. Clarke - University of Calgary
Publication Details: Lupus science & medicine, v 4(1), pp e000187-e000187
Publisher: Bmj Publishing Group
Number of pages: 6
Grant note: Canadian Institutes for Health Research (CIHR); Canadian Institutes of Health Research (CIHR) CA62006; CM 65923 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 0073 / Bloodwise HHSN261201500005C / U.S. Public Health Service from the National Cancer Institute, Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Intramural Research Program of the U.S. National Cancer Institute, National Institutes of Health Association pour la Recherche contre le Cancer (ARC); Fondation ARC pour la Recherche sur le Cancer; French National Research Agency (ANR) HHSN268201100046C; HHSN268201100001C; HHSN268201100002C; HHSN268201100003C; HHSN268201100004C; HHSN271201100004C / Fondation contre la Intramural Research Program of the National Institutes of Health, NCI, Division of Cancer Epidemiology and Genetics Michael Smith Foundation for Health Research UM1CA167552 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Canadian Cancer Society; Canadian Cancer Society (CCS) P30GM110766 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) Fondation de France American Cancer Society Institut National du Cancer (INCa); Institut National du Cancer (INCA) France
Resource Type: Journal article
Language: English
Academic Unit: Environmental and Occupational Health
Web of Science ID: WOS:000447607600007
Scopus ID: 2-s2.0-85037860713
Other Identifier: 991019168583204721

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Web of Science research areas: Rheumatology

Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

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