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Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection
Journal article   Peer reviewed

Lymph node architecture collapse and consequent modulation of FOXO3a pathway on memory T- and B-cells during HIV infection

Julien van Grevenynghe, Rabih Halwani, Nicolas Chomont, Petronela Ancuta, Yoav Peretz, Andre Tanel, Francesco A. Procopio, Yu shi, Elias A. Said, Elias K. Haddad, …
Seminars in immunology, v 20(3), pp 196-203
2008
DOI: https://doi.org/10.1016/j.smim.2008.07.008
PMID: 18757210
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

FOXO3a pathways HIV infection Lymph nodes architecture Memory B cell Memory T cell
Lymph nodes (LNs) represent the principal site where antigen-specific memory T- and B-cell responses are primed and differentiated into memory and effector cells. During chronic viral infections such as HIV, these lymphoid tissues undergo substantial structural changes. These changes are mostly caused by an imbalanced cytokine milieu, hyper-immune activation and collagen deposition leading to fibrotic LNs. The structural integrity of the LNs is essential to prime and maintain memory responses. Because cellular signalling events both up- and down-stream of FOXO3a are critical to the generation and the maintenance of lymphocyte memory, this review will focus on the interplay between the deregulation of the immune system caused by the virus and its impact on FOXO3a.

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27 citations in Web of Science
26 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Immunology
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