Journal article
Lymphatic Vessel Density as Prognostic Marker in Esophageal Adenocarcinoma
American journal of clinical pathology, v 131(1), pp 92-98
01 Jan 2009
PMID: 19095571
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We studied tumor lymphatic vascular density (L VD) as a predictive marker for the risk of lymph node (LN) metastasis and its relationship to other prognostic parameters and survival in 75 patients with esophageal adenocarcinoma. Samples were immunostained for D2-40, CD31, and vascular endothelial growth factor (VEGF). Microvessels were counted in densely vascular/lymphatic foci (hot spots) at x 400 field (0.17 mm(2)). Intensity of staining for VEGF was scored on a 2-tiered scale. CD31 microvessel counts showed significant correlation with tumor stage and patient survival (P < .01). D2-40 LVD demonstrated a significant correlation with LN metastases, lymphovascular invasion, and tumor stage (r = 0.45, r = 0.47, and r = 0.37, respectively) and with shorter disease-free survival. D2-40 detected lymphovascular invasion in 29 of 75 cases, more than with CD31 (23/75) and H&E (18/75). VEGF was expressed in 48 (64%) of 75 cases and was significantly correlated with lymphovascular invasion, LN metastases, and overall survival. Our study showed that angiogenesis and lymphangiogenesis have important roles in the progression of esophageal adenocarcinoma.
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Details
- Title
- Lymphatic Vessel Density as Prognostic Marker in Esophageal Adenocarcinoma
- Creators
- Reda S. Saad - Sunnybrook Health Science CentreJennifer L. Lindner - Sunnybrook Health Science CentreYulin Liu - Sunnybrook Health Science CentreJan F. Silverman - Drexel University
- Publication Details
- American journal of clinical pathology, v 131(1), pp 92-98
- Publisher
- Amer Soc Clinical Pathology
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000262314500013
- Scopus ID
- 2-s2.0-58549112794
- Other Identifier
- 991019169701404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pathology